Lack of Association between Interleukin 23R (IL-23R) rs10889677 Polymorphism and Inflammatory Bowel Disease Susceptibility In an Iranian Population

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Karimkhani Sara; Chaleshi Vahid; BALAII HEDIEH; TARBAN PEYMAN; NOURIAN MAHYAR; IRANI SHIVA; SHAHROKH SHABNAM; ASADZADEH AGHDAEI HAMID; MOHAMMAD ALIZADEH AMIR HOUSHANG; NOROUZINIA MOHSEN; ZALI MOHAMMAD REZA

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Journal: REPORTS OF BIOCHEMISTRY AND MOLECULAR BIOLOGY Year:2018 | Volume:7 | Issue:1 Page(s): 16-22

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Title

Lack of Association between Interleukin 23R (IL-23R) rs10889677 Polymorphism and Inflammatory Bowel Disease Susceptibility In an Iranian Population

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Keywords

Crohn’s disease

Inflammatory bowel diseases

Interleukin 23 receptor

rs10889677

Ulcerative colitis

Abstract

Background: Inflammatory bowel diseases (IBDs), which include Ulcerative colitis (UC) and Crohn’ s disease (CD), are inflammatory disorders that affect the gastrointestinal tract. A combination of inflammatory cytokines has an important role in IBD development. Genome-wide association studies have shown that polymorphisms in the interleukin-23R gene (IL-23R) increase susceptibility to IBD. The aim of this study was to investigate the IL-23R 3' UTR SNP to determine a potential association between genotype distribution and IBD. Methods: The case group included 102 IBD patients and the control group included 107 healthy individuals. IL-23R polymorphisms rs10889677 were genotyped using PCR-RFLP analysis. RFLP results were confirmed by direct sequencing. Results: The allele and genotype frequencies in patients and controls were evaluated and compared, and no significant association between this functional rs10889677 polymorphism and risk of IBD was observed (P=0. 587; adjusted OR: 0. 89; 95% CI: 0. 597-1. 339). We also found no significant association between CD (14. 71%) and UC (85. 29%) patients in allele or genotype levels (P>0. 05). Conclusions: Our results suggest that the rs10889677 A>C polymorphism is not a potential prognostic marker in Iranian patients with IBD.

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APA: Copy

Karimkhani, Sara, Chaleshi, Vahid, BALAII, HEDIEH, TARBAN, PEYMAN, NOURIAN, MAHYAR, IRANI, SHIVA, SHAHROKH, SHABNAM, ASADZADEH AGHDAEI, HAMID, MOHAMMAD ALIZADEH, AMIR HOUSHANG, NOROUZINIA, MOHSEN, & ZALI, MOHAMMAD REZA. (2018). Lack of Association between Interleukin 23R (IL-23R) rs10889677 Polymorphism and Inflammatory Bowel Disease Susceptibility In an Iranian Population. REPORTS OF BIOCHEMISTRY AND MOLECULAR BIOLOGY, 7(1), 16-22. SID. https://sid.ir/paper/753075/en

Vancouver: Copy

Karimkhani Sara, Chaleshi Vahid, BALAII HEDIEH, TARBAN PEYMAN, NOURIAN MAHYAR, IRANI SHIVA, SHAHROKH SHABNAM, ASADZADEH AGHDAEI HAMID, MOHAMMAD ALIZADEH AMIR HOUSHANG, NOROUZINIA MOHSEN, ZALI MOHAMMAD REZA. Lack of Association between Interleukin 23R (IL-23R) rs10889677 Polymorphism and Inflammatory Bowel Disease Susceptibility In an Iranian Population. REPORTS OF BIOCHEMISTRY AND MOLECULAR BIOLOGY[Internet]. 2018;7(1):16-22. Available from: https://sid.ir/paper/753075/en

IEEE: Copy

Sara Karimkhani, Vahid Chaleshi, HEDIEH BALAII, PEYMAN TARBAN, MAHYAR NOURIAN, SHIVA IRANI, SHABNAM SHAHROKH, HAMID ASADZADEH AGHDAEI, AMIR HOUSHANG MOHAMMAD ALIZADEH, MOHSEN NOROUZINIA, and MOHAMMAD REZA ZALI, “Lack of Association between Interleukin 23R (IL-23R) rs10889677 Polymorphism and Inflammatory Bowel Disease Susceptibility In an Iranian Population,” REPORTS OF BIOCHEMISTRY AND MOLECULAR BIOLOGY, vol. 7, no. 1, pp. 16–22, 2018, [Online]. Available: https://sid.ir/paper/753075/en

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