PROTECTIVE ROLE OF CYCLOSPORINE ON THE MODEL SIMULATED THE ROTATIONAL NODAL ARRHYTHMIA (AVNRT) BY USING EXTRACELLULAR FIELD POTENTIAL RECORDINGS OF ISOLATED ATRIOVENTRICULAR-NODE OF RABBIT

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

KHORI VAHID; SHARIAT NEJAD SEPIDEH; ALIZADEH ALI MOHAMMAD; YAZDI HAMID REZA; POURABOUK MONA; BADAGHABADI FAKHRI; MOHEIMANI HAMID REZA; CHANGIZI SHIMA; RAJAEI MARYAM; NAYEBPOUR MOHSEN

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Physiology and Pharmacology Year:2011 | Volume:15 | Issue:2 Page(s): 250-259

Download Full-Text

Persian Verion

View:

603

Download:

Cites:

Information Journal Paper

Title

PROTECTIVE ROLE OF CYCLOSPORINE ON THE MODEL SIMULATED THE ROTATIONAL NODAL ARRHYTHMIA (AVNRT) BY USING EXTRACELLULAR FIELD POTENTIAL RECORDINGS OF ISOLATED ATRIOVENTRICULAR-NODE OF RABBIT

Author(s)

Keywords

ATRIO-VENTRICULAR NODEQ2

CYCLOSPORINEQ3

SUPRAVENTRICULAR ARRHYTHMIAQ3

Abstract

Introduction: Recent studies have shown acute cardioprotective effects of CYCLOSPORINE. The aim of the present study was to determine the protective role of CYCLOSPORINE on the model simulated the rotational nodal arrhythmia (AVNRT) by using extracellular field potential recordings of isolated atrioventricular-node (AV-node) of rabbit.Methods: This study was performed on isolated double-perfused AV-node of male New Zealand rabbits (1.5-2.5 kg) in one group (n=7). Basic and rate-dependent stimulation protocols (recovery, facilitation, fatigue) and arrhythmia threshold (index of refractoriness) and % Gap incidence were measured for assessment of electrophysiological properties of the AV- node. All stimulation protocols were repeated in control step and in the presence of various cumulative concentrations of CYCLOSPORINE (0.5 - 10 mm).Results: CYCLOSPORINE prolonged the effective refractory period from 114.3±7.9 to 142±7.3 msec at the concentration of 10 mm. It also prolonged the functional refractory period from 162±3.3 to 178.6±5 msec and increased the time of Wenckebach at the concentrations of 5-10 mM. Various concentrations of CYCLOSPORINE increased fatigue and reached a significant level at 10 mm. Gap incidence was 82%, 16.6% and 20% in the control and treatments with 0.5 and 10 mm of CYCLOSPORINE, respectively.Conclusion: Block of MPTP by CYCLOSPORINE caused inhibition of basic and rate-dependent properties of atrioventricular node. CYCLOSPORINE, by raising the threshold of arrhythmia, could be possibly considered as an anti- AVNRT drug.

Cites

No record.

References

No record.

Cite

APA: Copy

KHORI, VAHID, SHARIAT NEJAD, SEPIDEH, ALIZADEH, ALI MOHAMMAD, YAZDI, HAMID REZA, POURABOUK, MONA, BADAGHABADI, FAKHRI, MOHEIMANI, HAMID REZA, CHANGIZI, SHIMA, RAJAEI, MARYAM, & NAYEBPOUR, MOHSEN. (2011). PROTECTIVE ROLE OF CYCLOSPORINE ON THE MODEL SIMULATED THE ROTATIONAL NODAL ARRHYTHMIA (AVNRT) BY USING EXTRACELLULAR FIELD POTENTIAL RECORDINGS OF ISOLATED ATRIOVENTRICULAR-NODE OF RABBIT. PHYSIOLOGY AND PHARMACOLOGY, 15(2), 250-259. SID. https://sid.ir/paper/75308/en

Vancouver: Copy

KHORI VAHID, SHARIAT NEJAD SEPIDEH, ALIZADEH ALI MOHAMMAD, YAZDI HAMID REZA, POURABOUK MONA, BADAGHABADI FAKHRI, MOHEIMANI HAMID REZA, CHANGIZI SHIMA, RAJAEI MARYAM, NAYEBPOUR MOHSEN. PROTECTIVE ROLE OF CYCLOSPORINE ON THE MODEL SIMULATED THE ROTATIONAL NODAL ARRHYTHMIA (AVNRT) BY USING EXTRACELLULAR FIELD POTENTIAL RECORDINGS OF ISOLATED ATRIOVENTRICULAR-NODE OF RABBIT. PHYSIOLOGY AND PHARMACOLOGY[Internet]. 2011;15(2):250-259. Available from: https://sid.ir/paper/75308/en

IEEE: Copy

VAHID KHORI, SEPIDEH SHARIAT NEJAD, ALI MOHAMMAD ALIZADEH, HAMID REZA YAZDI, MONA POURABOUK, FAKHRI BADAGHABADI, HAMID REZA MOHEIMANI, SHIMA CHANGIZI, MARYAM RAJAEI, and MOHSEN NAYEBPOUR, “PROTECTIVE ROLE OF CYCLOSPORINE ON THE MODEL SIMULATED THE ROTATIONAL NODAL ARRHYTHMIA (AVNRT) BY USING EXTRACELLULAR FIELD POTENTIAL RECORDINGS OF ISOLATED ATRIOVENTRICULAR-NODE OF RABBIT,” PHYSIOLOGY AND PHARMACOLOGY, vol. 15, no. 2, pp. 250–259, 2011, [Online]. Available: https://sid.ir/paper/75308/en

Related Journal Papers