Improvement of dermal delivery of tetracycline using vesicular nanostructures

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

Hasanpouri Azam; LOTFIPOUR FARZANEH; GHANBARZADEH SAEED; HAMISHEHKAR HAMED

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: RESEARCH IN PHARMACEUTICAL SCIENCES (RPS) Year:2018 | Volume:13 | Issue:5 Page(s): 385-393

Download Full-Text

View:

142

Download:

116

Cites:

Information Journal Paper

Title

Improvement of dermal delivery of tetracycline using vesicular nanostructures

Author(s)

Hasanpouri Azam | LOTFIPOUR FARZANEH | GHANBARZADEH SAEED | HAMISHEHKAR HAMED | Issue Writer Certificate

Keywords

Acne

Dermal drug delivery

Liposome

Nanoparticle

Tetracycline

Transferosome

Abstract

The objective of this investigation was to study the potential use of nanoLiposomes and nanotransfersomes in dermal delivery of Tetracycline hydrochloride (TC) for Acne treatment. Vesicular nanostructures were prepared by thin film hydration method and evaluated for their size, zeta potential, morphology, and entrapment efficiency. Minimal inhibitory concentration values of TC-loaded vesicles were evaluated and compared with TC aqueous solution against Staphylococcus epidermis. In vitro drug release and ex vivo drug permeation through the excised rat skin were performed to assess drug delivery efficiency. Particle size, zeta potential, and entrapment efficiency of prepared nanoLiposomes and nanotransfersomes were found to be 75 and 78 nm, 17 and 7 mV, and 45 and 55%, respectively. Antimicrobial analysis indicated that there was no difference between vesicular formulations and aqueous solution of TC. In vitro drug release study indicated that nanoLiposomes could release TC 2. 6 folds more than nanotransfersomes, and skin permeation study showed that the permeability of TC-loaded nanotransfersomes was 1. 6 times higher than nanoLiposomes which was also confirmed by fluorescence microscope imaging. These findings concluded that nanoliposomal and especially nanotransfersomal formulations could be proposed as the potential approach for better therapeutic performance of TC against Acne.

Cites

No record.

References

No record.

Cite

APA: Copy

Hasanpouri, Azam, LOTFIPOUR, FARZANEH, GHANBARZADEH, SAEED, & HAMISHEHKAR, HAMED. (2018). Improvement of dermal delivery of tetracycline using vesicular nanostructures. RESEARCH IN PHARMACEUTICAL SCIENCES (RPS), 13(5), 385-393. SID. https://sid.ir/paper/753191/en

Vancouver: Copy

Hasanpouri Azam, LOTFIPOUR FARZANEH, GHANBARZADEH SAEED, HAMISHEHKAR HAMED. Improvement of dermal delivery of tetracycline using vesicular nanostructures. RESEARCH IN PHARMACEUTICAL SCIENCES (RPS)[Internet]. 2018;13(5):385-393. Available from: https://sid.ir/paper/753191/en

IEEE: Copy

Azam Hasanpouri, FARZANEH LOTFIPOUR, SAEED GHANBARZADEH, and HAMED HAMISHEHKAR, “Improvement of dermal delivery of tetracycline using vesicular nanostructures,” RESEARCH IN PHARMACEUTICAL SCIENCES (RPS), vol. 13, no. 5, pp. 385–393, 2018, [Online]. Available: https://sid.ir/paper/753191/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops