A Molecular Study on Drug Delivery System Based on Carbon Nanotube Compared to Silicon Carbide Nanotube for Encapsulation of Platinum-Based Anticancer Drug

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Khatti Zahra; Hashemianzadeh Seyed Majid; SHAFIEI SEYED ALI

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Journal: Advanced Pharmaceutical Bulletin Year:2018 | Volume:8 | Issue:1 Page(s): 163-167

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Title

A Molecular Study on Drug Delivery System Based on Carbon Nanotube Compared to Silicon Carbide Nanotube for Encapsulation of Platinum-Based Anticancer Drug

Author(s)

Khatti Zahra | Hashemianzadeh Seyed Majid | SHAFIEI SEYED ALI | Issue Writer Certificate

Keywords

Molecular Dynamic Simulation

Carbon nanotube

Silicon Carbide nanotube

Platinum-based anticancer drug

Abstract

Purpose: Drug delivery has a critical role in the treatment of cancer, in particular, Carbon nanotubes for their potential use in various biomedical devices and therapies. From many other materials which could be more biocompatible and biodegradable and which could form single-walled nanotubes, silicon carbide was selected. Methods: To compare two drug delivery systems based on single-walled nanotubes, Molecular Dynamic Simulations were applied and encapsulation behavior of the drug carboplatin was investigated inside the Silicon Carbide nanotube and the Carbon nanotube. Results: Localization of the carboplatin inside the nanotubes indicated that the carboplatin moves throughout the tubes and possesses a greater probability of finding the drug molecule along the nanotubes in the first quarter of the tubes. The energy analysis exhibited the lowest free energy of binding belongs to the encapsulation of the drug carboplatin in the Silicon Carbide nanotube, about-145 Kcal/mol. Conclusion: The results confirmed that the Silicon Carbide nanotube is a more suitable model than the Carbon nanotube for drug delivery system based on nanotubes as a carrier of Platinum-based anticancer drugs.

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APA: Copy

Khatti, Zahra, Hashemianzadeh, Seyed Majid, & SHAFIEI, SEYED ALI. (2018). A Molecular Study on Drug Delivery System Based on Carbon Nanotube Compared to Silicon Carbide Nanotube for Encapsulation of Platinum-Based Anticancer Drug. ADVANCED PHARMACEUTICAL BULLETIN, 8(1), 163-167. SID. https://sid.ir/paper/753231/en

Vancouver: Copy

Khatti Zahra, Hashemianzadeh Seyed Majid, SHAFIEI SEYED ALI. A Molecular Study on Drug Delivery System Based on Carbon Nanotube Compared to Silicon Carbide Nanotube for Encapsulation of Platinum-Based Anticancer Drug. ADVANCED PHARMACEUTICAL BULLETIN[Internet]. 2018;8(1):163-167. Available from: https://sid.ir/paper/753231/en

IEEE: Copy

Zahra Khatti, Seyed Majid Hashemianzadeh, and SEYED ALI SHAFIEI, “A Molecular Study on Drug Delivery System Based on Carbon Nanotube Compared to Silicon Carbide Nanotube for Encapsulation of Platinum-Based Anticancer Drug,” ADVANCED PHARMACEUTICAL BULLETIN, vol. 8, no. 1, pp. 163–167, 2018, [Online]. Available: https://sid.ir/paper/753231/en

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