Immunization of C57BL/6 Mice with GRA2 Combined with MPL Conferred Partial Immune Protection against Toxoplasma gondii

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BABAIE JALAL; AMIRI SAMIRA; Homayoun Robab; AZIMI EBRAHIM; MOHABATI REYHANEH; Berizi Mahboobe; Sadaie M.Reza; GOLKAR MAJID

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Journal: Iranian Biomedical Journal Year:2018 | Volume:22 | Issue:1 Page(s): 22-32

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Title

Immunization of C57BL/6 Mice with GRA2 Combined with MPL Conferred Partial Immune Protection against Toxoplasma gondii

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Keywords

Immunization

GRA2

Toxoplasma

MPL

Abstract

Background: We have previously reported that Immunization with GRA2 antigen of Toxoplasma gondii induces protective immunity in CBA/J (H2k) and BALB/c mice (H2d). We aimed to examine whether Immunization of a distinct strain of rodent with recombinant dense granule antigens (GRA2) combined with monophosphorryl lipid A (MPL) adjuvant elicits protective immune response against T. gondii. Methods: C57BL/6 (H2b haplotype) mice were immunized with GRA2, formulated in MPL adjuvant. Results: Strong humoral response, predominantly of IgG1 subclass and cellular response, IFN-γ , was detected at three weeks post Immunization. Mice immunized with GRA2 had significantly (p < 0. 01) fewer brain cysts than those in the adjuvant group, upon challenge infection. Despite the production of a strong antibody response, IFN-γ production and brain cyst reduction were not significant when the immunized mice were infected four months after the Immunization. Conclusions: We can conclude that GRA2 Immunization partially protects against T. gondii infection in C57BL/6 mice, though the potency and longevity of this antigen as a standalone vaccine may vary in distinct genetic backgrounds. This observation further emphasizes the utility of GRA2 for incorporation into a multi-antigenic vaccine against T. gondii.

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APA: Copy

BABAIE, JALAL, AMIRI, SAMIRA, Homayoun, Robab, AZIMI, EBRAHIM, MOHABATI, REYHANEH, Berizi, Mahboobe, Sadaie, M.Reza, & GOLKAR, MAJID. (2018). Immunization of C57BL/6 Mice with GRA2 Combined with MPL Conferred Partial Immune Protection against Toxoplasma gondii. IRANIAN BIOMEDICAL JOURNAL, 22(1), 22-32. SID. https://sid.ir/paper/753478/en

Vancouver: Copy

BABAIE JALAL, AMIRI SAMIRA, Homayoun Robab, AZIMI EBRAHIM, MOHABATI REYHANEH, Berizi Mahboobe, Sadaie M.Reza, GOLKAR MAJID. Immunization of C57BL/6 Mice with GRA2 Combined with MPL Conferred Partial Immune Protection against Toxoplasma gondii. IRANIAN BIOMEDICAL JOURNAL[Internet]. 2018;22(1):22-32. Available from: https://sid.ir/paper/753478/en

IEEE: Copy

JALAL BABAIE, SAMIRA AMIRI, Robab Homayoun, EBRAHIM AZIMI, REYHANEH MOHABATI, Mahboobe Berizi, M.Reza Sadaie, and MAJID GOLKAR, “Immunization of C57BL/6 Mice with GRA2 Combined with MPL Conferred Partial Immune Protection against Toxoplasma gondii,” IRANIAN BIOMEDICAL JOURNAL, vol. 22, no. 1, pp. 22–32, 2018, [Online]. Available: https://sid.ir/paper/753478/en

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