Synthesis and Characterization of a Novel Fe3O4-SiO2@Gold Core-Shell Biocompatible Magnetic Nanoparticles for Biological and Medical Applications

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SADEGHI MEISAM; JAHANSHAHI MOHSEN; Javadian Hamedreza

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Journal Paper

Paper Information

Journal: NANOMEDICINE RESEARCH JOURNAL Year:2019 | Volume:4 | Issue:3 Page(s): 193-203

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Title

Synthesis and Characterization of a Novel Fe3O4-SiO2@Gold Core-Shell Biocompatible Magnetic Nanoparticles for Biological and Medical Applications

Author(s)

SADEGHI MEISAM | JAHANSHAHI MOHSEN | Javadian Hamedreza | Issue Writer Certificate

Keywords

Bagg Albino/C Mice

Biocompatible Magnetic

Nanoparticles

Biological And Medical

Applications

Core-Shell Sio2-Fe3O4@Gold

Muscle Cancer Model

Abstract

Objectives: In this study, an efficient and fast method has been developed for synthesis of a novel magnetite Nanoparticles Fe3O4@SiO2@Gold as an efficient boronated nanodrug carrier. Application and characterization of core-shell iron oxide (Fe3O4/γ-Fe2O3) magnetic Nanoparticles (MNPs) with an inner silica shell and outer of Gold shell (Fe3O4-SiO2@Gold (FSG)) in Boron Neutrons Capture Therapy (BNCT) highlighted. The main problem dealing with cancer cells is that the tumor and normal cells ones are mixed without a map of the boron accumulation. Methods: The content of the discussion include the possibility of a FSG mediated by liposome as the boron carriers for the transfer of boron compound to tumor tissue. Furthermore, folate receptor was considered as an appropriate substrate that has great potential to attach to tumor. The present work aimed to study boron biodistribution in the muscle cancer animal model in Bagg Albino (BALB/c) mice employing PEGylated liposome-encapsulated FSG formulations. Results: The predetermined boron concentration was obtained to be 20-35 mg 10B/g. Samples of the tumor tissue, such as kidney, liver, lung, heart, skin, spleen, brain, stomach, and bone were taken as post-administration at different times to measure boron content by Inductively Coupled Plasma (ICP) analysis. The results showed the existence of GLUT-5 expression as an erythrocyte-type glucose transporter protein in a wide variety of tumor cells. Conclusions: Fe3O4-SiO2 Nanoparticles are highly biocompatible with biological materials and also Gold shell exposes the magnetic properties.

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