Efficacy of insulin targeted gene therapy for type 1 diabetes mellitus: A systematic review and meta-analysis of rodent studies

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

Rahimi Ghiasi Moosa; MOHAMMADI HAMED; Symonds Michael E.; TABEI SEYED MOHAMMAD BAGHER; Salehi ahmad reza; JAFARPOUR SIMA; Norouzi Barough Leila; Rahimi Elnaz; Amirkhani Zohreh; MIRAGHAJANI MARYAM; SALEHI RASOUL

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Iranian Journal of Basic Medical Sciences Year:2020 | Volume:23 | Issue:4 Page(s): 406-415

Download Full-Text

View:

175

Download:

139

Cites:

Information Journal Paper

Title

Efficacy of insulin targeted gene therapy for type 1 diabetes mellitus: A systematic review and meta-analysis of rodent studies

Author(s)

Keywords

Gene therapy

Insulin

Meta-analysis

Non-viral vector

Type 1 diabetes mellitus

Viral vector

Abstract

Diabetes mellitus (DM) is a major worldwide public health challenge, for which Gene therapy offers a potential therapeutic approach. To date, no systematic review or Meta-analysis has been published in this area, so we examined all relevant published studies on rodents to elucidate the overall effects of Gene therapy on bodyweight, intraperitoneal glucose tolerance test (IPGTT), fasting blood glucose, and Insulin in animals with type 1 DM. The Cochrane Library, PubMed, Embase, ISI Web of Science, SCOPUS, and Google Scholar were systematically searched for potentially relevant studies. Mean± standard deviation (SD) was pooled using a random-effects model. After the primary search, out of 528 studies identified, 16 studies were in concordance with predefined criteria and selected for the final assessment. Of these, 12 studies used viral manipulation, and 4 employed Viral vector/fa?page=1&sort=1&ftyp=all&fgrp=all&fyrs=all" target="_blank">Non-Viral vectors for gene delivery. The Meta-analysis showed Gene therapy with a Viral vector decreased mean IPGTT (-12. 69 mmol/l, P<0. 001), fasting blood glucose (-13. 51 mmol/l, P<0. 001), Insulin (398. 28 pmol/l, P<0. 001), and bodyweight (24. 22 g, P<0. 001), whereas Viral vector/fa?page=1&sort=1&ftyp=all&fgrp=all&fyrs=all" target="_blank">Non-Viral vectors reduced fasting glucose (-29. 95 mmol/l, P<0. 001) and elevated Insulin (114. 92 pmol/l, P<0. 001). Gene therapy has favorable effects on alleviating type 1 DM related factors in diabetic rodents.

Cites

No record.

References

No record.

Cite

APA: Copy

Rahimi Ghiasi, Moosa, MOHAMMADI, HAMED, Symonds, Michael E., TABEI, SEYED MOHAMMAD BAGHER, Salehi, ahmad reza, JAFARPOUR, SIMA, Norouzi Barough, Leila, Rahimi, Elnaz, Amirkhani, Zohreh, MIRAGHAJANI, MARYAM, & SALEHI, RASOUL. (2020). Efficacy of insulin targeted gene therapy for type 1 diabetes mellitus: A systematic review and meta-analysis of rodent studies. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 23(4), 406-415. SID. https://sid.ir/paper/753782/en

Vancouver: Copy

Rahimi Ghiasi Moosa, MOHAMMADI HAMED, Symonds Michael E., TABEI SEYED MOHAMMAD BAGHER, Salehi ahmad reza, JAFARPOUR SIMA, Norouzi Barough Leila, Rahimi Elnaz, Amirkhani Zohreh, MIRAGHAJANI MARYAM, SALEHI RASOUL. Efficacy of insulin targeted gene therapy for type 1 diabetes mellitus: A systematic review and meta-analysis of rodent studies. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2020;23(4):406-415. Available from: https://sid.ir/paper/753782/en

IEEE: Copy

Moosa Rahimi Ghiasi, HAMED MOHAMMADI, Michael E. Symonds, SEYED MOHAMMAD BAGHER TABEI, ahmad reza Salehi, SIMA JAFARPOUR, Leila Norouzi Barough, Elnaz Rahimi, Zohreh Amirkhani, MARYAM MIRAGHAJANI, and RASOUL SALEHI, “Efficacy of insulin targeted gene therapy for type 1 diabetes mellitus: A systematic review and meta-analysis of rodent studies,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 23, no. 4, pp. 406–415, 2020, [Online]. Available: https://sid.ir/paper/753782/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops