Preparation and in vivo evaluation of nanoliposomes containing vancomycin after intravitreal injection in albino rabbits

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ABRISHAMI MAJID; Motamed Shariati Mehrdad; MALAEKEH NIKOUEI BIZHAN; TAJANI AMINEH SADAT; MAHMOUDI ASMA; ABRISHAMI MOJTABA; KHAMENEH BAHMAN

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Journal: Iranian Journal of Basic Medical Sciences Year:2020 | Volume:23 | Issue:4 Page(s): 551-555

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Title

Preparation and in vivo evaluation of nanoliposomes containing vancomycin after intravitreal injection in albino rabbits

Author(s)

Keywords

Drug delivery

Endophthalmitis

MRSA

Nanopliposomes

Vancomycin

Abstract

Objective(s): The in vivo efficacy of nanoliposomal formulation of Vancomycin against methicillinresistant Staphylococcus aureus (MRSA) assessed. Materials and Methods: Nanoliposomal formulations were prepared and characterized. The in vivo study was carried out on rabbits which received liquid culture medium containing MRSA under anesthesia. After 48 hr, the eyes treated with the liposomal and free form of Vancomycin. The rabbits were euthanized at predesignate intervals at 12, 24, 48, 96, 144 hr intervals injection. The antibacterial activity of different Vancomycin formulations was assayed by the time killing method. Results: The zeta potential, mean sizes and encapsulation efficacy of liposomal Vancomycin were 29. 7 mV, 381. 93± 30. 13 nm and 47%, respectively. The results of time– killing studies indicated that the liposomal formula was more effective than the free form of Vancomycin. Conclusion: The results of this study revealed that liposomal Vancomycin formulation is a powerful nano-antibacterial agent to combat infectious Endophthalmitis.

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APA: Copy

ABRISHAMI, MAJID, Motamed Shariati, Mehrdad, MALAEKEH NIKOUEI, BIZHAN, TAJANI, AMINEH SADAT, MAHMOUDI, ASMA, ABRISHAMI, MOJTABA, & KHAMENEH, BAHMAN. (2020). Preparation and in vivo evaluation of nanoliposomes containing vancomycin after intravitreal injection in albino rabbits. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 23(4), 551-555. SID. https://sid.ir/paper/753790/en

Vancouver: Copy

ABRISHAMI MAJID, Motamed Shariati Mehrdad, MALAEKEH NIKOUEI BIZHAN, TAJANI AMINEH SADAT, MAHMOUDI ASMA, ABRISHAMI MOJTABA, KHAMENEH BAHMAN. Preparation and in vivo evaluation of nanoliposomes containing vancomycin after intravitreal injection in albino rabbits. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2020;23(4):551-555. Available from: https://sid.ir/paper/753790/en

IEEE: Copy

MAJID ABRISHAMI, Mehrdad Motamed Shariati, BIZHAN MALAEKEH NIKOUEI, AMINEH SADAT TAJANI, ASMA MAHMOUDI, MOJTABA ABRISHAMI, and BAHMAN KHAMENEH, “Preparation and in vivo evaluation of nanoliposomes containing vancomycin after intravitreal injection in albino rabbits,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 23, no. 4, pp. 551–555, 2020, [Online]. Available: https://sid.ir/paper/753790/en

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