Blockade of Hypoxia: The Impact on Tumor Growth in an Experimental Tumor Model

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Kheshtchin Nasim; ARAB SAMANEH; HADJATI JAMSHID

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Journal Paper

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Journal: ImmunoRegulation Year:2019 | Volume:2 | Issue:1 Page(s): 35-40

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Title

Blockade of Hypoxia: The Impact on Tumor Growth in an Experimental Tumor Model

Author(s)

Kheshtchin Nasim | ARAB SAMANEH | HADJATI JAMSHID | Issue Writer Certificate

Keywords

Cancer

Hypoxia-Inducible Factor-1α(HIF-1α)

Hypoxia

PX-478

Foxp3

VEGF

Abstract

Background: Tumor microenvironment is an active factor participating in immunoregulation, thereby preventing immunosurveillance and limiting the efficacy of antiCancer therapies. Hypoxia as a major characteristic of solid tumors causes the expression of Hypoxia-Inducible Factor-1α (HIF-1α ). This is a transcription factor that mediates hypoxic responses of tumor cells and involves in the expression of tumor immunosuppression-related genes. Materials and Methods: In this study, we used a mouse 4T1 breast Cancer model. Results: Our obtained data revealed that in vivo administration of PX-478, an inhibitor of oxygen sensitive HIF-1α , reduced the expression of Forkhead box P3 (Foxp3) transcript, a molecule that is directly controlled by HIF-1. The level of vascular endothelial growth factor, another gene controlled by HIF-1, remained unchanged. The observed results were in correlation with delayed tumor growth in tumor-bearing mice. Conclusion: Our findings indicate that the reduction in Foxp3 expression through HIF-1α inhibition using PX-478 may contribute to tumor regression.

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APA: Copy

Kheshtchin, Nasim, ARAB, SAMANEH, & HADJATI, JAMSHID. (2019). Blockade of Hypoxia: The Impact on Tumor Growth in an Experimental Tumor Model. IMMUNOREGULATION, 2(1), 35-40. SID. https://sid.ir/paper/754211/en

Vancouver: Copy

Kheshtchin Nasim, ARAB SAMANEH, HADJATI JAMSHID. Blockade of Hypoxia: The Impact on Tumor Growth in an Experimental Tumor Model. IMMUNOREGULATION[Internet]. 2019;2(1):35-40. Available from: https://sid.ir/paper/754211/en

IEEE: Copy

Nasim Kheshtchin, SAMANEH ARAB, and JAMSHID HADJATI, “Blockade of Hypoxia: The Impact on Tumor Growth in an Experimental Tumor Model,” IMMUNOREGULATION, vol. 2, no. 1, pp. 35–40, 2019, [Online]. Available: https://sid.ir/paper/754211/en

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