The Relationship Between Serum Interleukin-6 Level and Chronic Urticaria

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BABAIE DELARA; NABAVI MOHAMMAD; ARSHI SABA; Gorjipour Houshang; DAROUGAR SEPIDEH

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Journal Paper

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Journal: ImmunoRegulation Year:2019 | Volume:2 | Issue:1 Page(s): 41-46

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Title

The Relationship Between Serum Interleukin-6 Level and Chronic Urticaria

Author(s)

Keywords

Chronic urticaria

Cytokine

Interleukin

6 (IL

Tumor Necrosis Factor

α(TNF

α)

Interferon

ϒ(IFN

ϒ)

Abstract

Background: The immunologic profile of Chronic urticaria is not only important for diagnostic purposes, but also for therapeutic approaches. This study evaluated the serum levels of Interleukin-6 (IL-6), Tumor Necrosis Factor-α (TNF-α ) and Interferon-ϒ (IFN-ϒ ) in patients with Chronic urticaria to find a biomarker. Materials and Methods: Forty-one patients with Chronic urticaria referring to the Allergy Outpatient Clinic of Rasoul Akram Hospital and 20 healthy control subjects were enrolled in the study. A questionnaire was filled and the disease activity score was determined in a one-week period for every patient. All patients underwent basic laboratory tests in addition to the Autologous Serum Skin Test. Their serum IL-6, TNF-α , and IFN-ϒ levels were also evaluated. Results: The patients were divided into two groups comprising of 20 and 21 participants according to the results of Autologous Serum Skin Tests. The serum IL-6 levels were elevated in the patients’ group (P=0. 015). However, there was no significant difference between the patients with Chronic urticaria and healthy controls in the serum levels of TNF-α (P=0. 25), and IFN-ϒ (P=0. 55), neither in the exact state nor by the Mann-Whitney U test. Conclusion: Serum IL-6 level was elevated in patients with Chronic urticaria, but the serum levels of IFN-ϒ and TNF-α were not significantly elevated.

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APA: Copy

BABAIE, DELARA, NABAVI, MOHAMMAD, ARSHI, SABA, Gorjipour, Houshang, & DAROUGAR, SEPIDEH. (2019). The Relationship Between Serum Interleukin-6 Level and Chronic Urticaria. IMMUNOREGULATION, 2(1), 41-46. SID. https://sid.ir/paper/754212/en

Vancouver: Copy

BABAIE DELARA, NABAVI MOHAMMAD, ARSHI SABA, Gorjipour Houshang, DAROUGAR SEPIDEH. The Relationship Between Serum Interleukin-6 Level and Chronic Urticaria. IMMUNOREGULATION[Internet]. 2019;2(1):41-46. Available from: https://sid.ir/paper/754212/en

IEEE: Copy

DELARA BABAIE, MOHAMMAD NABAVI, SABA ARSHI, Houshang Gorjipour, and SEPIDEH DAROUGAR, “The Relationship Between Serum Interleukin-6 Level and Chronic Urticaria,” IMMUNOREGULATION, vol. 2, no. 1, pp. 41–46, 2019, [Online]. Available: https://sid.ir/paper/754212/en

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