Synthesis of 1, 5 and 2, 5-disubstituted tetrazoles and their evaluation as antimicrobial agents

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SAFAEI GHOMI JAVAD; Paymard Samani Soleiman; Zahraie Zohre; SHAHBAZI ALAVI HOSSEIN

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Journal Paper

Paper Information

Journal: NANOMEDICINE RESEARCH JOURNAL Year:2019 | Volume:4 | Issue:2 Page(s): 91-100

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Title

Synthesis of 1, 5 and 2, 5-disubstituted tetrazoles and their evaluation as antimicrobial agents

Author(s)

SAFAEI GHOMI JAVAD | Paymard Samani Soleiman | Zahraie Zohre | SHAHBAZI ALAVI HOSSEIN | Issue Writer Certificate

Keywords

5-Disubstituted

Tetrazoles

Antimicrobial

NiO Nanoparticles

Tetrazolate Salts

Abstract

Treatments of Tetrazolate Salts, malononitrile and sodium azide using NiO Nanoparticles with benzyl bromide gave the corresponding 1, 5-and 2, 5-Disubstituted Tetrazoles. Reaction of Tetrazolate Salts with 2, 4′-dibromoacetophenone by NiO Nanoparticles provided 2, 5-Disubstituted derivatives as an only isomer. The structures of Tetrazoles were characterized by 1H and 13C NMR spectra, FT-IR spectra, MS and elemental analysis. Use of simple and readily accessible starting materials, excellent yields, reusability of the catalyst, short reaction times, low amount of catalyst are some advantages of this protocol. Their Antimicrobial activity has been tested in vitro against Gram positive bacteria; Gram negative bacteria and fungi. Four compounds have only moderate growth inhibitory effects against Gram positive bacteria. The Antimicrobial screening suggests that compounds 5h; 6h; 5g and 6g have only medium growth inhibitory effects against Gram positive bacteria. Among the newly synthesized compounds; good Antimicrobial activity was observed for compound 6g against Staphylococcus epidermidis (MIC value 125 μ g/ml).

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References

CuO-NiO Nano composites: Synthesis, Characterization, and Cytotoxicity evaluation

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APA: Copy

SAFAEI GHOMI, JAVAD, Paymard Samani, Soleiman, Zahraie, Zohre, & SHAHBAZI ALAVI, HOSSEIN. (2019). Synthesis of 1, 5 and 2, 5-disubstituted tetrazoles and their evaluation as antimicrobial agents. NANOMEDICINE RESEARCH JOURNAL, 4(2), 91-100. SID. https://sid.ir/paper/754562/en

Vancouver: Copy

SAFAEI GHOMI JAVAD, Paymard Samani Soleiman, Zahraie Zohre, SHAHBAZI ALAVI HOSSEIN. Synthesis of 1, 5 and 2, 5-disubstituted tetrazoles and their evaluation as antimicrobial agents. NANOMEDICINE RESEARCH JOURNAL[Internet]. 2019;4(2):91-100. Available from: https://sid.ir/paper/754562/en

IEEE: Copy

JAVAD SAFAEI GHOMI, Soleiman Paymard Samani, Zohre Zahraie, and HOSSEIN SHAHBAZI ALAVI, “Synthesis of 1, 5 and 2, 5-disubstituted tetrazoles and their evaluation as antimicrobial agents,” NANOMEDICINE RESEARCH JOURNAL, vol. 4, no. 2, pp. 91–100, 2019, [Online]. Available: https://sid.ir/paper/754562/en

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