Intralesional Injection of the Measles– Mumps– Rubella Vaccine into Resistant Palmoplantar Warts: A Randomized Controlled Trial

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REZAI MOHAMMAD SADEGH; Ghasempouri Hiva; Asqary Marzidareh Ozra; YAZDANI CHERATI JAMSHID; RAHMATPOUR ROKNI GHASEM

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Journal: IRANIAN JOURNAL OF MEDICAL SCIENCES (IJMS) Year:2019 | Volume:44 | Issue:1 Page(s): 10-17

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Title

Intralesional Injection of the Measles– Mumps– Rubella Vaccine into Resistant Palmoplantar Warts: A Randomized Controlled Trial

Author(s)

Keywords

Injections

Intralesional

Measles–mumps–rubella vaccine

Warts

Abstract

Background: Common resistant-to-therapy Warts pose a challenge to both clinicians and patients. Among many destructive and immunotherapeutic options, no single, fully effective treatment has been suggested yet. Many investigations, including those using Intralesional antigen administrations, have demonstrated that cellular immunity plays a major role in the clearance of human papilloma virus (HPV) infection. The aim of the present study was to evaluate the effects of the Intralesional injection of the measles– mumps– rubella (MMR) vaccine into resistant-to-treatment palmoplantar Warts and its complications. Methods: In this single-blind, randomized, controlled clinical trial, 60 cases with resistant-to-therapy palmoplantar Warts referring to the Dermatology Clinic of Bou-Ali Sina Hospital of Sari between June 2015 and 2016 were randomly assigned to 2 equal groups: the MMR Group received Intralesional MMR and the Placebo Group was given saline injection. The Injections were administered at 2-week intervals until complete clearance was achieved or for a maximum of 5 Injections (<5 Injections at 2-week intervals). The study protocol was registered in the Iranian Registry of Randomised Clinical Trials (ID: IRCT2016101027636N3), and the statistical analyses were performed using SPSS, version 17. 0. The χ 2 test and the F-test were used as appropriate, and a P value less than 0. 05 was considered statistically significant. Results: Complete clearance was observed in 65. 2% (14⁄ 23) of the patients presenting with resistant-to-therapy palmoplantar Warts in the MMR Group and 23. 85% (5/21) in the Placebo Group (P=0. 021). Recurrence was not observed in any of the completely cured patients at 6 months’ follow-up. Conclusion: Intralesional immunotherapy with the MMR vaccine may result in a desirable therapeutic response and can be used as an effective and safe treatment option for palmoplantar Warts, particularly persistent ones.

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APA: Copy

REZAI, MOHAMMAD SADEGH, Ghasempouri, Hiva, Asqary Marzidareh, Ozra, YAZDANI CHERATI, JAMSHID, & RAHMATPOUR ROKNI, GHASEM. (2019). Intralesional Injection of the Measles– Mumps– Rubella Vaccine into Resistant Palmoplantar Warts: A Randomized Controlled Trial. IRANIAN JOURNAL OF MEDICAL SCIENCES (IJMS), 44(1), 10-17. SID. https://sid.ir/paper/754807/en

Vancouver: Copy

REZAI MOHAMMAD SADEGH, Ghasempouri Hiva, Asqary Marzidareh Ozra, YAZDANI CHERATI JAMSHID, RAHMATPOUR ROKNI GHASEM. Intralesional Injection of the Measles– Mumps– Rubella Vaccine into Resistant Palmoplantar Warts: A Randomized Controlled Trial. IRANIAN JOURNAL OF MEDICAL SCIENCES (IJMS)[Internet]. 2019;44(1):10-17. Available from: https://sid.ir/paper/754807/en

IEEE: Copy

MOHAMMAD SADEGH REZAI, Hiva Ghasempouri, Ozra Asqary Marzidareh, JAMSHID YAZDANI CHERATI, and GHASEM RAHMATPOUR ROKNI, “Intralesional Injection of the Measles– Mumps– Rubella Vaccine into Resistant Palmoplantar Warts: A Randomized Controlled Trial,” IRANIAN JOURNAL OF MEDICAL SCIENCES (IJMS), vol. 44, no. 1, pp. 10–17, 2019, [Online]. Available: https://sid.ir/paper/754807/en

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