Effect of Multiple Intraperitoneal Injections of Human Bone Marrow Mesenchymal Stem Cells on Cuprizone Model of Multiple Sclerosis

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MARZBAN MOHSEN; MOUSAVIZADEH KAZEM; BAKHSHAYESH MASOOMEH; VOUSOOGHI NASIM; VAKILZADEH GELAREH; Torkaman Boutorabi Anahita

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Journal: Iranian Biomedical Journal Year:2018 | Volume:22 | Issue:5 Page(s): 312-321

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Title

Effect of Multiple Intraperitoneal Injections of Human Bone Marrow Mesenchymal Stem Cells on Cuprizone Model of Multiple Sclerosis

Author(s)

Keywords

Cuprizone

Mesenchymal stem cells

Mice

Multiple sclerosis

Abstract

Background: Bone marrow Mesenchymal stem cells (BM-MSCs) elicit neuroprotective effects, and their repair ability has been investigated in different experimental models. We aimed to investigate the effect of multiple i. p. BM-MSCs injections in the Cuprizone model of Multiple sclerosis in Mice. Methods: Adult male C57BL/6 Mice (n = 40) were fed a regular diet or a diet containing Cuprizone (0. 2% w/w) for six weeks. Bone marrow samples were taken from patients with spinal cord injury. BM-MSCs (2 × 106 in 1 milliliter medium) were administered intraperitoneally for two consecutive weeks at the end of the forth weeks of Cuprizone administration. Animals (n = 12) were perfused with 10% paraformaldehyde at the end of sixth week. The brains were sectioned coronally in 6-8-μ m thickness (-2. 3 to 1. 8 mm from bregma). The sections were stained by luxol fast blue-cresyl violet, and images were captured via a microscope. Demyelination ratio was estimated in corpus callosum in a blind manner. A quantitative real-time PCR was used to measure the myelin basic protein gene expression at sixth week. Results: Histologically, Cuprizone induced demyelination in the corpus callosum. Demyelinated area was diminished in the corpus callosum of cell-administered group. Cuprizone could decrease myelin-binding protein mRNAs expression in corpus callosum, which was significantly recovered after BM-MSCs injections. Conclusion: Our data indicated a remyelination potency of multiple i. p. BM-MSCs in the Cuprizone model of Multiple sclerosis in Mice.

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APA: Copy

MARZBAN, MOHSEN, MOUSAVIZADEH, KAZEM, BAKHSHAYESH, MASOOMEH, VOUSOOGHI, NASIM, VAKILZADEH, GELAREH, & Torkaman Boutorabi, Anahita. (2018). Effect of Multiple Intraperitoneal Injections of Human Bone Marrow Mesenchymal Stem Cells on Cuprizone Model of Multiple Sclerosis. IRANIAN BIOMEDICAL JOURNAL, 22(5), 312-321. SID. https://sid.ir/paper/755234/en

Vancouver: Copy

MARZBAN MOHSEN, MOUSAVIZADEH KAZEM, BAKHSHAYESH MASOOMEH, VOUSOOGHI NASIM, VAKILZADEH GELAREH, Torkaman Boutorabi Anahita. Effect of Multiple Intraperitoneal Injections of Human Bone Marrow Mesenchymal Stem Cells on Cuprizone Model of Multiple Sclerosis. IRANIAN BIOMEDICAL JOURNAL[Internet]. 2018;22(5):312-321. Available from: https://sid.ir/paper/755234/en

IEEE: Copy

MOHSEN MARZBAN, KAZEM MOUSAVIZADEH, MASOOMEH BAKHSHAYESH, NASIM VOUSOOGHI, GELAREH VAKILZADEH, and Anahita Torkaman Boutorabi, “Effect of Multiple Intraperitoneal Injections of Human Bone Marrow Mesenchymal Stem Cells on Cuprizone Model of Multiple Sclerosis,” IRANIAN BIOMEDICAL JOURNAL, vol. 22, no. 5, pp. 312–321, 2018, [Online]. Available: https://sid.ir/paper/755234/en

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