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Information Journal Paper

Title

Changes in the Hypothalamic-Pituitary-Gonadal Axis in Adult Male Rats Poisoned with Proteus and Biscaya Insecticides

Pages

  155-162

Abstract

 Background: Insecticides may have negative effects on reproductive organs. Given the interaction between Leptin and the hypothalamic-pituitary-gonadal (HPG) axis, we sought to investigate the changes in Leptin and the HPG axis in adult male Rats poisoned with Proteus and Biscaya insecticides. Methods: Our experimental subjects were 110 adult male Wistar Rats (80– 90 days of age; average weight=200– 210 g). They were randomly split into 11 groups of 10 Rats: control, sham, and 9 experimental groups namely treatment with 2. 75, 5. 5, and 11 mg/kg/BW of Proteus, treatment with 1. 5, 3, and 6 mg/kg/BW of Biscaya, treatment with 2. 75 mg/kg/BW of Proteus+1. 5 mg/kg/BW of Biscaya, treatment with 5. 5 mg/kg/ BW of Proteus+3 mg/kg/BW of Biscaya, and treatment with 11 mg/kg/BW of Proteus+6 mg/kg/BW of Biscaya. Intraperitoneal injections were performed over a 14-day period. For bloodletting at the end of the experiment, blood samples were withdrawn from the Rats in order to investigate the serum concentration of luteinizing hormone (LH), follicle-stimulating hormone (FSH), gonadotropin-releasing hormone (GnRH), Testosterone, and Leptin. The data were analyzed using SPSS, version 16, via ANOVA and the Duncan test. A P value equal to or less than 0. 05 was considered statistically significant. Results: Our comparisons between the experimental groups (average and maximum compound concentrations of Proteus and Biscaya) and the control group showed a significant decrease in the mean serum levels of FSH (P=0. 001), LH (P=0. 001), GnRH (P=0. 001), Testosterone (P=0. 005), and Leptin (P=0. 001) in all the experimental groups in a dose-dependent manner. Conclusion: Proteus and Biscaya decreased GnRH, LH, FSH, and Testosterone by reducing the serum level of Leptin in the hypothalamus in a dose-dependent manner.

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    APA: Copy

    Solhjou, Karamat Allah, HOSSEINI, SEYED EBRAHIM, VAHDATI, AKBAR, & EDALATMANESH, MOHAMMAD AMIN. (2019). Changes in the Hypothalamic-Pituitary-Gonadal Axis in Adult Male Rats Poisoned with Proteus and Biscaya Insecticides. IRANIAN JOURNAL OF MEDICAL SCIENCES (IJMS), 44(2), 155-162. SID. https://sid.ir/paper/755321/en

    Vancouver: Copy

    Solhjou Karamat Allah, HOSSEINI SEYED EBRAHIM, VAHDATI AKBAR, EDALATMANESH MOHAMMAD AMIN. Changes in the Hypothalamic-Pituitary-Gonadal Axis in Adult Male Rats Poisoned with Proteus and Biscaya Insecticides. IRANIAN JOURNAL OF MEDICAL SCIENCES (IJMS)[Internet]. 2019;44(2):155-162. Available from: https://sid.ir/paper/755321/en

    IEEE: Copy

    Karamat Allah Solhjou, SEYED EBRAHIM HOSSEINI, AKBAR VAHDATI, and MOHAMMAD AMIN EDALATMANESH, “Changes in the Hypothalamic-Pituitary-Gonadal Axis in Adult Male Rats Poisoned with Proteus and Biscaya Insecticides,” IRANIAN JOURNAL OF MEDICAL SCIENCES (IJMS), vol. 44, no. 2, pp. 155–162, 2019, [Online]. Available: https://sid.ir/paper/755321/en

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