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Information Journal Paper

Title

Cobalt Oxide Nanoparticles/Graphene/Ionic Liquid Crystal Modified Carbon Paste Electrochemical Sensor for Ultra-sensitive Determination of a Narcotic Drug

Pages

  110-121

Abstract

 Purpose: Drug-abuse, namely Morphine (MO) affects the metabolism of neurotransmitters such as Dopamine (DA). Therefore, it is crucial to devise a sensitive sensing technique to simultaneously determine both compounds in real samples. Methods: The fabrication of the sensor is based on in situ modification of a carbon paste (CP) electrode with Cobalt oxide nanoparticles, Graphene, and Ionic liquid crystal in presence of sodium dodecyl sulfate; CoGILCCP-SDS. The modified sensor is characterized using scanning electron microscopy, electrochemical impedance spectroscopy and voltammetry measurements. Results: Electron transfer kinetics and analytical performance of the proposed sensor were enhanced due to the synergistic role of all the modifiers. The simultaneous determination of MO and DA achieved low detection limits of 0. 54 nmol L− 1 and 0. 25 nmol L− 1, respectively. Besides, a carbon-based electrochemical sensor is fabricated for the nano-molar determination of MO in real samples and formulations. The sensor showed fouling resistance and anti-interference ability in presence of other species in human fluids. The real sample analysis of MO was successfully achieved with good recovery results in urine samples and pharmaceutical tablets. Linear dynamic range, sensitivity, detection limit and quantification limit of MO in urine were 5 nmol L− 1 to 0. 6 μ mol L− 1, 6. 19 μ A/μ mol L-1, 0. 484 nmol L− 1 and 1. 61 nmol L− 1, respectively. Conclusion: This sensor has great ability to be extended for electrochemical applications in assaying of many drugs.

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    • Cite

    APA: Copy

    Atta, Nada Farouk, Galal, Ahmed, El Ads, Ekram Hamdy, & Hassan, Samar Hamed. (2019). Cobalt Oxide Nanoparticles/Graphene/Ionic Liquid Crystal Modified Carbon Paste Electrochemical Sensor for Ultra-sensitive Determination of a Narcotic Drug. ADVANCED PHARMACEUTICAL BULLETIN, 9(1), 110-121. SID. https://sid.ir/paper/755770/en

    Vancouver: Copy

    Atta Nada Farouk, Galal Ahmed, El Ads Ekram Hamdy, Hassan Samar Hamed. Cobalt Oxide Nanoparticles/Graphene/Ionic Liquid Crystal Modified Carbon Paste Electrochemical Sensor for Ultra-sensitive Determination of a Narcotic Drug. ADVANCED PHARMACEUTICAL BULLETIN[Internet]. 2019;9(1):110-121. Available from: https://sid.ir/paper/755770/en

    IEEE: Copy

    Nada Farouk Atta, Ahmed Galal, Ekram Hamdy El Ads, and Samar Hamed Hassan, “Cobalt Oxide Nanoparticles/Graphene/Ionic Liquid Crystal Modified Carbon Paste Electrochemical Sensor for Ultra-sensitive Determination of a Narcotic Drug,” ADVANCED PHARMACEUTICAL BULLETIN, vol. 9, no. 1, pp. 110–121, 2019, [Online]. Available: https://sid.ir/paper/755770/en

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