Association of microRNA gene polymorphisms with Type 2 diabetes mellitus: A systematic review and meta‑ analysis

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

GHOLAMI MORTEZA; ASGARBEIK SAEEDEH; RAZI FARIDEH; NASLI ESFAHANI ENSIEH; Zoughi Marzieh; Vahidi Aida; LARIJANI BAGHER; MOHAMMAD AMOLI MAHSA

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS) Year:2020 | Volume:25 | Issue:6 Page(s): 0-0

Download Full-Text

View:

211

Download:

242

Cites:

Information Journal Paper

Title

Association of microRNA gene polymorphisms with Type 2 diabetes mellitus: A systematic review and meta‑ analysis

Author(s)

Keywords

MicroRNAs

polymorphism

Type 2 diabetes

Abstract

Background: Type 2 diabetes mellitus (T2DM) is a metabolic disorder with growing prevalence and increasing economic burden. Based on the role of genetics and epigenetic factors on T2DM, we aimed to carry a systematic review and meta‑ analysis for all miRNA gene polymorphisms and risk of T2DM. Materials and Methods: A computerized literature search was carried out on PubMed, Web of Science, Scopus, Embase, as well as references of relevant review/meta‑ analysis. Key search terms were “ Diabetes Mellitus, Type 2, ” “ MicroRNAs, ” and “ polymorphism, Single Nucleotide. ” All types of observational studies from January 1, 1992, to November 30, 2019, were included, without language restriction. Data analysis was performed using R programming language (3. 5. 2). Level of heterogeneity was obtained by Cochran’ s Q test (P ˂ 0. 05), and subgroup analysis was performed based on ethnicity. Results: Thirty‑ two polymorphisms from fifteen articles were included. Meta‑ analysis was carried out based on minor allele frequencies. Seven studies with 2193 cases and 3963 controls were included for rs2910164 polymorphism. In subgroup analysis, there were significant results in Caucasian population in dominant model (odds ratio [OR] =1. 12; 95% confidence interval [CI]: 0. 83– 1. 51), homozygote model (OR = 1. 78; 95% CI: 1. 06– 3. 00), heterozygote model (OR = 1. 77; 95% CI: 1. 03– 3. 05), and recessive model (OR = 1. 78; 95% CI: 1. 07– 2. 96). Four studies with 2085 cases and 1933 controls were included for rs895819 polymorphism. Overall, there was no significant result for association with rs895819, but subgroup analysis revealed that minor allele significantly decreased the risk of T2DM in Caucasians by recessive model (OR = 0. 34; 95% CI: 0. 18– 0. 66), dominant model (OR = 0. 70; 95% CI: 0. 52– 0. 94), homozygote model (OR = 0. 32; 95% CI: 0. 16– 0. 62), heterozygote model (OR = 0. 37; 95% CI: 0. 19– 0. 74), allelic model (OR = 0. 67; 95% CI: 0. 52– 0. 85). Conclusion: The minor allele of rs2910164 may increase the risk of T2DM by leading to lower level of miR‑ 146a. In contrast, minor allele of rs895819 may decrease the risk of T2DM by leading to higher level of miR‑ 27a.

Cites

No record.

References

No record.

Cite

APA: Copy

ASGARBEIK, SAEEDEH, RAZI, FARIDEH, NASLI ESFAHANI, ENSIEH, Zoughi, Marzieh, Vahidi, Aida, LARIJANI, BAGHER, & MOHAMMAD AMOLI, MAHSA. (2020). Association of microRNA gene polymorphisms with Type 2 diabetes mellitus: A systematic review and meta‑ analysis. JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS), 25(6), 0-0. SID. https://sid.ir/paper/755824/en

Vancouver: Copy

ASGARBEIK SAEEDEH, RAZI FARIDEH, NASLI ESFAHANI ENSIEH, Zoughi Marzieh, Vahidi Aida, LARIJANI BAGHER, MOHAMMAD AMOLI MAHSA. Association of microRNA gene polymorphisms with Type 2 diabetes mellitus: A systematic review and meta‑ analysis. JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS)[Internet]. 2020;25(6):0-0. Available from: https://sid.ir/paper/755824/en

IEEE: Copy

SAEEDEH ASGARBEIK, FARIDEH RAZI, ENSIEH NASLI ESFAHANI, Marzieh Zoughi, Aida Vahidi, BAGHER LARIJANI, and MAHSA MOHAMMAD AMOLI, “Association of microRNA gene polymorphisms with Type 2 diabetes mellitus: A systematic review and meta‑ analysis,” JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS), vol. 25, no. 6, pp. 0–0, 2020, [Online]. Available: https://sid.ir/paper/755824/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops