Brief Report: Effects of delta-Aminolevulinic Acid Dehydratase Gene Polymorphism on Hematological Parameters and Kidney Function of Lead-exposed Workers

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Sobhi Siha Mona; Abdel Hamid Shaker Dalia; Saad Teleb Hebatalla; Rashed Laila Ahmed

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Paper Information

Journal: INTERNATIONAL JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL MEDICINE Year:2019 | Volume:10 | Issue:2 Page(s): 89-93

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Title

Brief Report: Effects of delta-Aminolevulinic Acid Dehydratase Gene Polymorphism on Hematological Parameters and Kidney Function of Lead-exposed Workers

Author(s)

Sobhi Siha Mona | Abdel Hamid Shaker Dalia | Saad Teleb Hebatalla | Rashed Laila Ahmed | Issue Writer Certificate

Keywords

Explosive agents

Lead

Porphobilinogen synthase

Polymorphism

genetic

beta 2-Microglobulin

Abstract

Lead exposure is associated with several health hazards among workers with different individual responses. We conducted this study to determine the possible effects of Lead exposure on hematological parameters and kidney function of a group of Egyptian ammunition workers and the interaction of aminolevulinic acid dehydratase (ALAD) G177C gene Polymorphisms as an effect modifier. Significant differences were observed between exposed workers with ALAD1-1 and ALAD1-2 genotypes in terms of blood Lead level, hematological parameters and kidney function. It seems that δ-ALAD gene Polymorphism may be an effect modifier and a marker of genetic susceptibility to Lead toxicity.

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Cites

Evaluation of total and differential white blood cell counts in workers exposed to lead

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APA: Copy

Sobhi Siha, Mona, Abdel Hamid Shaker, Dalia, Saad Teleb, Hebatalla, & Rashed, Laila Ahmed. (2019). Brief Report: Effects of delta-Aminolevulinic Acid Dehydratase Gene Polymorphism on Hematological Parameters and Kidney Function of Lead-exposed Workers. INTERNATIONAL JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL MEDICINE, 10(2), 89-93. SID. https://sid.ir/paper/756203/en

Vancouver: Copy

Sobhi Siha Mona, Abdel Hamid Shaker Dalia, Saad Teleb Hebatalla, Rashed Laila Ahmed. Brief Report: Effects of delta-Aminolevulinic Acid Dehydratase Gene Polymorphism on Hematological Parameters and Kidney Function of Lead-exposed Workers. INTERNATIONAL JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL MEDICINE[Internet]. 2019;10(2):89-93. Available from: https://sid.ir/paper/756203/en

IEEE: Copy

Mona Sobhi Siha, Dalia Abdel Hamid Shaker, Hebatalla Saad Teleb, and Laila Ahmed Rashed, “Brief Report: Effects of delta-Aminolevulinic Acid Dehydratase Gene Polymorphism on Hematological Parameters and Kidney Function of Lead-exposed Workers,” INTERNATIONAL JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL MEDICINE, vol. 10, no. 2, pp. 89–93, 2019, [Online]. Available: https://sid.ir/paper/756203/en

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