Analytical Investigation of the Possible Chemical Interaction of Methyldopa with Some Reducing Carbohydrates Used as Pharmaceutical Excipients

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Siahi Mohammadreza; Rahimi Soma; MONAJJEMZADEH FARNAZ

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Journal Paper

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Journal: Advanced Pharmaceutical Bulletin Year:2018 | Volume:8 | Issue:4 Page(s): 657-666

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Information Journal Paper

Title

Analytical Investigation of the Possible Chemical Interaction of Methyldopa with Some Reducing Carbohydrates Used as Pharmaceutical Excipients

Author(s)

Siahi Mohammadreza | Rahimi Soma | MONAJJEMZADEH FARNAZ | Issue Writer Certificate

Keywords

Pharmaceuticals

Thermal Methods

IR Spectroscopy

Mass Analysis

Incompatibility

Excipients

Abstract

Purpose: Assessment of drug substance and Excipients compatibility is an important issue during pre-formulation studies as well as the quality control of pharmaceutical dosage forms. In this study, potential Incompatibility between methyldopa and reducing Excipients was evaluated using physicochemical methods. Methods: Dextrose and lactose (anhydrous & monohydrate) were selected as reducing carbohydrates. The initial Incompatibility was studied with DSC and FTIR on binary mixtures with 1: 1 mass ratio. Results were confirmed using HPLC studies coupled with mass spectrometry. Results: The DSC curves indicated the elimination of the melting endotherm of methyldopa in the binary mixtures. A new peak at 1719 cm-1 was observed in the FTIR spectra that can be attributed to the loss of type one amine functionality. The m/z of the proposed compound was observed in the mass spectra. Conclusion: The potential Incompatibility of Methyldopa with reducing carbohydrates was established using physicochemical methods.

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APA: Copy

Siahi, Mohammadreza, Rahimi, Soma, & MONAJJEMZADEH, FARNAZ. (2018). Analytical Investigation of the Possible Chemical Interaction of Methyldopa with Some Reducing Carbohydrates Used as Pharmaceutical Excipients. ADVANCED PHARMACEUTICAL BULLETIN, 8(4), 657-666. SID. https://sid.ir/paper/756249/en

Vancouver: Copy

Siahi Mohammadreza, Rahimi Soma, MONAJJEMZADEH FARNAZ. Analytical Investigation of the Possible Chemical Interaction of Methyldopa with Some Reducing Carbohydrates Used as Pharmaceutical Excipients. ADVANCED PHARMACEUTICAL BULLETIN[Internet]. 2018;8(4):657-666. Available from: https://sid.ir/paper/756249/en

IEEE: Copy

Mohammadreza Siahi, Soma Rahimi, and FARNAZ MONAJJEMZADEH, “Analytical Investigation of the Possible Chemical Interaction of Methyldopa with Some Reducing Carbohydrates Used as Pharmaceutical Excipients,” ADVANCED PHARMACEUTICAL BULLETIN, vol. 8, no. 4, pp. 657–666, 2018, [Online]. Available: https://sid.ir/paper/756249/en

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