Evaluation of Aminoglycosides Consumption in Open Heart Surgery Based on the Defined Daily Dose Index

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Gholizadeh Shirdarreh Golpar; ESLAMI GOHAR; SOLEIMANI ARIA; SALEHIFAR EBRAHIM

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Journal Paper

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Journal: Pharmaceutical and Biomedical Research Year:2020 | Volume:6 | Issue:2 Page(s): 105-114

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Title

Evaluation of Aminoglycosides Consumption in Open Heart Surgery Based on the Defined Daily Dose Index

Author(s)

Gholizadeh Shirdarreh Golpar | ESLAMI GOHAR | SOLEIMANI ARIA | SALEHIFAR EBRAHIM | Issue Writer Certificate

Keywords

Intensive Care Units (ICU)

Rational use

Cardiac surgery

Microbial resistance

Prophylactic antibiotic

Aminoglycosides

Defined Daily Dose (DDD)

Abstract

Background: Resistance to antibiotics, including Aminoglycosides (AMG) is one of the problems associated with inappropriate administration of broad-spectrum antibiotics. Objectives: This study aimed to assess the clinical features of Aminoglycosides consumption based on the Defined Daily Dose (DDD) index in open heart surgery. Methods: This study was done on 268 patients who underwent heart surgery during 2015 and 2016. Clinical and demographic characteristics, laboratory data, and aminoglycosiderelated data such as dose and the total duration of administration were collected through a questionnaire designed by the authors. The patients’ DDD/100 bed-days were calculated, too. Results: Out of 268 patients, 170 patients (63. 4%) were male. The Mean± SD age of the patients was 60. 65± 10. 71 years and the Mean± SD duration of hospitalization was 12. 19± 7. 02 days. Ischemic heart disease was the most prevalent cause of hospitalization. The Mean duration of receiving Aminoglycosides was 3. 61 days. In 134 patients (50%), creatinine clearance was less than 60 mL/min during Aminoglycosides administration. In 25 patients (9. 32%), a 50% increase in serum creatinine during receiving Aminoglycosides was observed. Creatinine clearance had not been calculated for any patient. Conclusion: In this study, monitoring the side effects of Aminoglycosides and the serum concentration was not routinely performed. Dose adjustment of Aminoglycosides based on renal function test was not considered in a large number of patients and as a result, the dose was inappropriate in many patients. Therefore, it is recommended that the guidelines of drug usage were followed and the patients were monitored more closely for side effects.

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APA: Copy

Gholizadeh Shirdarreh, Golpar, ESLAMI, GOHAR, SOLEIMANI, ARIA, & SALEHIFAR, EBRAHIM. (2020). Evaluation of Aminoglycosides Consumption in Open Heart Surgery Based on the Defined Daily Dose Index. PHARMACEUTICAL AND BIOMEDICAL RESEARCH, 6(2), 105-114. SID. https://sid.ir/paper/756881/en

Vancouver: Copy

Gholizadeh Shirdarreh Golpar, ESLAMI GOHAR, SOLEIMANI ARIA, SALEHIFAR EBRAHIM. Evaluation of Aminoglycosides Consumption in Open Heart Surgery Based on the Defined Daily Dose Index. PHARMACEUTICAL AND BIOMEDICAL RESEARCH[Internet]. 2020;6(2):105-114. Available from: https://sid.ir/paper/756881/en

IEEE: Copy

Golpar Gholizadeh Shirdarreh, GOHAR ESLAMI, ARIA SOLEIMANI, and EBRAHIM SALEHIFAR, “Evaluation of Aminoglycosides Consumption in Open Heart Surgery Based on the Defined Daily Dose Index,” PHARMACEUTICAL AND BIOMEDICAL RESEARCH, vol. 6, no. 2, pp. 105–114, 2020, [Online]. Available: https://sid.ir/paper/756881/en

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