Effect of PI3K/Akt Signaling Pathway on PRAS40Thr246 Phosphorylation in Gastric Cancer Cells

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LU Yizhuo; LI Lianghui; WU Guoyang; ZHUO Huiqin; LIU Guoyan; CAI Jianchun

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Journal Paper

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Journal: Iranian Journal of Public Health Year:2019 | Volume:48 | Issue:12 Page(s): 2196-2204

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Title

Effect of PI3K/Akt Signaling Pathway on PRAS40Thr246 Phosphorylation in Gastric Cancer Cells

Author(s)

Keywords

Gastric cancer

LY294002

MK-2206

Phosphorylation

PI3K/Akt signaling pathway

PRAS40Thr246

Abstract

Background: We aimed to investigate the effect of PI3K/Akt signaling pathway on PRAS40Thr246 Phosphorylation in Gastric cancer cells. Methods: The study was conducted from April 2017 to January 2018 in Zhongshan Hospital, Xiamen University, Xiamen, China. Gastric cancer cells were divided into three groups: Gastric cancer cell group, LY294002 group and MK-2206 group. Specific tests were conducted accordingly. Results: Inhibition of PI3K/Akt signaling pathway activation and PRAS40Thr246 Phosphorylation could inhibit proliferation and invasion and promote apoptosis of Gastric cancer cells, and PRAS40Thr246 Phosphorylation could activate PI3K/Akt signaling pathway. Conclusion: The levels of PI3K/Akt signaling pathway related proteins and p-PRAS40Thr246 were significantly increased in Gastric cancer cells. p-PRAS40-Thr246 was able to reflect the activation of the PI3K/Akt signaling pathway, reflecting the sensitivity of the PI3K/Akt signaling pathway to inhibitors.

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APA: Copy

LU, Yizhuo, LI, Lianghui, WU, Guoyang, ZHUO, Huiqin, LIU, Guoyan, & CAI, Jianchun. (2019). Effect of PI3K/Akt Signaling Pathway on PRAS40Thr246 Phosphorylation in Gastric Cancer Cells. IRANIAN JOURNAL OF PUBLIC HEALTH, 48(12), 2196-2204. SID. https://sid.ir/paper/757522/en

Vancouver: Copy

LU Yizhuo, LI Lianghui, WU Guoyang, ZHUO Huiqin, LIU Guoyan, CAI Jianchun. Effect of PI3K/Akt Signaling Pathway on PRAS40Thr246 Phosphorylation in Gastric Cancer Cells. IRANIAN JOURNAL OF PUBLIC HEALTH[Internet]. 2019;48(12):2196-2204. Available from: https://sid.ir/paper/757522/en

IEEE: Copy

Yizhuo LU, Lianghui LI, Guoyang WU, Huiqin ZHUO, Guoyan LIU, and Jianchun CAI, “Effect of PI3K/Akt Signaling Pathway on PRAS40Thr246 Phosphorylation in Gastric Cancer Cells,” IRANIAN JOURNAL OF PUBLIC HEALTH, vol. 48, no. 12, pp. 2196–2204, 2019, [Online]. Available: https://sid.ir/paper/757522/en

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