Zingerone attenuates Bleomycin-Induced Pulmonary Fibrosis in Rats

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Mansouri Mohammad Taghi; RAJABI VARDANJANI HOSSEIN; HEMMATI ALI ASGHAR; TABANDEH MOHAMMAD REZA; REZAIE ANAHITA; Pashmforosh Marzieh; AHMADI ANGALI KAMBIZ

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Journal: Jundishapur Journal of Natural Pharmaceutical Products Year:2019 | Volume:14 | Issue:1 Page(s): 0-0

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Title

Zingerone attenuates Bleomycin-Induced Pulmonary Fibrosis in Rats

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Keywords

Zingerone

Pulmonary Fibrosis

Bleomycin

Antioxidant

Abstract

Background: Idiopathic Pulmonary Fibrosis (IPF) is a progressive lung disorder that results in severe respiratory failure and death. The main characteristic of IPF is excess oxidative stress, fibroblast activation, increased collagen deposition, and multiple fibrotic lesions. Zingerone exhibits potent Antioxidant, anti-inflammatory, and anti-fibrotic activities. Objectives: The aim of the study was to evaluate the protective effect of Zingerone on Bleomycin-induced Pulmonary Fibrosis (PF) and underlying mechanisms in rats. Methods: PF was induced by Bleomycin (5 mg/kg, intratracheally) in male Sprague-Dawley rats and then, Zingerone (10-40 mg/kg, orally) was administrated for 21 days’ post-Bleomycin-instillation. After euthanizing the rats, the biochemical and histopathological markers of lung tissue were determined. Results: The findings showed that Bleomycin significantly increased inflammatory and fibrotic responses, the level of malondialdehyde (MDA), the influx of inflammatory cells into the bronchoalveolar fluid (BALF), and hydroxyproline content of the lung (P < 0. 01). In addition, the level of glutathione (GSH), the activity of superoxide dismutase (SOD) and glutathione peroxidase (GPx) decreased in the lung of Bleomycin-instilled rats (P < 0. 01). However, Zingerone (20 and 40 mg/kg) significantly decreased histopathological injuries in H&E (Hematoxylin and eosin) and Masson’ s trichrome-stained sections, hydroxyproline content and infiltration of leukocytes into BALF and oxidative markers, in a dose-dependent manner (P < 0. 01). In addition, Zingerone (40 mg/kg) significantly reduced the level of MDA in Bleomycin-instilled rats (P < 0. 01). Conclusions: These findings suggest that Zingerone has protective effects against Bleomycin-induced PF, which may be due to its anti-inflammatory and Antioxidant activity.

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APA: Copy

Mansouri, Mohammad Taghi, RAJABI VARDANJANI, HOSSEIN, HEMMATI, ALI ASGHAR, TABANDEH, MOHAMMAD REZA, REZAIE, ANAHITA, Pashmforosh, Marzieh, & AHMADI ANGALI, KAMBIZ. (2019). Zingerone attenuates Bleomycin-Induced Pulmonary Fibrosis in Rats. JUNDISHAPUR JOURNAL OF NATURAL PHARMACEUTICAL PRODUCTS, 14(1), 0-0. SID. https://sid.ir/paper/757551/en

Vancouver: Copy

Mansouri Mohammad Taghi, RAJABI VARDANJANI HOSSEIN, HEMMATI ALI ASGHAR, TABANDEH MOHAMMAD REZA, REZAIE ANAHITA, Pashmforosh Marzieh, AHMADI ANGALI KAMBIZ. Zingerone attenuates Bleomycin-Induced Pulmonary Fibrosis in Rats. JUNDISHAPUR JOURNAL OF NATURAL PHARMACEUTICAL PRODUCTS[Internet]. 2019;14(1):0-0. Available from: https://sid.ir/paper/757551/en

IEEE: Copy

Mohammad Taghi Mansouri, HOSSEIN RAJABI VARDANJANI, ALI ASGHAR HEMMATI, MOHAMMAD REZA TABANDEH, ANAHITA REZAIE, Marzieh Pashmforosh, and KAMBIZ AHMADI ANGALI, “Zingerone attenuates Bleomycin-Induced Pulmonary Fibrosis in Rats,” JUNDISHAPUR JOURNAL OF NATURAL PHARMACEUTICAL PRODUCTS, vol. 14, no. 1, pp. 0–0, 2019, [Online]. Available: https://sid.ir/paper/757551/en

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