مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

video

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

sound

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Version

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

View:

117
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Download:

64
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Cites:

Information Journal Paper

Title

Histopathological Evaluation and Analysis of Immunohistochemical Expression of Bcl-2 Oncoprotein in Colorectal Carcinoma

Pages

  317-321

Abstract

 Background & Objective: Colorectal cancer is the third most prevalent malignancy with high mortality rate, necessitating markers that predict survival and guide the treatment. Previous studies have examined the immunohistochemical expression of Bcl-2, an apoptotic marker, in colorectal carcinoma, but results have been contradictory. To evaluate the histopathological features of colorectal carcinoma, immunohistochemical expression of Bcl-2 must be analyzed to find out statistical association of Bcl-2 expression with certain Prognostic factors histopathologic type, grade and TNM staging. Methods: This prospective study was conducted on the colectomy specimens of colorectal carcinoma, over a period of two years. The tumor morphology and Bcl-2 status were evaluated by Immunohistochemistry in each case. Results: The study included 58 cases, with mean patient age of 47. 07 years and male: female ratio of 1. 89: 1. Bcl-2 positivity was seen in 32. 7% of the cases. Weak, moderate, and strong expression of Bcl-2 was seen in 12. 1%, 12. 1%, and 8. 5% of cases respectively. Even though early stages of colorectal carcinoma showed greater frequency of Bcl-2 expression than advanced stages (36. 3% versus 28%), however this association was not statistically significant. Conclusion: Lack of statistically significant correlation between Bcl-2 immuno-histochemical expression and prognostic parameters like tumor grade and stage, suggests that Bcl-2 immunoexpression may not be a significant prognostic marker in colorectal carcinoma.

Cites

  • No record.

    • References

  • No record.

    • Cite

    APA: Copy

    Shilpa, T.Patil, Clement, Wilfred D., & Prasanna, Shetty B.. (2019). Histopathological Evaluation and Analysis of Immunohistochemical Expression of Bcl-2 Oncoprotein in Colorectal Carcinoma. IRANIAN JOURNAL OF PATHOLOGY (IJP), 14(4), 317-321. SID. https://sid.ir/paper/758164/en

    Vancouver: Copy

    Shilpa T.Patil, Clement Wilfred D., Prasanna Shetty B.. Histopathological Evaluation and Analysis of Immunohistochemical Expression of Bcl-2 Oncoprotein in Colorectal Carcinoma. IRANIAN JOURNAL OF PATHOLOGY (IJP)[Internet]. 2019;14(4):317-321. Available from: https://sid.ir/paper/758164/en

    IEEE: Copy

    T.Patil Shilpa, Wilfred D. Clement, and Shetty B. Prasanna, “Histopathological Evaluation and Analysis of Immunohistochemical Expression of Bcl-2 Oncoprotein in Colorectal Carcinoma,” IRANIAN JOURNAL OF PATHOLOGY (IJP), vol. 14, no. 4, pp. 317–321, 2019, [Online]. Available: https://sid.ir/paper/758164/en

    Related Journal Papers

  • No record.

    • Related Seminar Papers

  • No record.

    • Related Plans

  • No record.

    • Recommended Workshops






    Move to top
    telegram sharing button
    whatsapp sharing button
    linkedin sharing button
    twitter sharing button
    email sharing button
    email sharing button
    email sharing button
    sharethis sharing button