Immune Modulatory Effects of Hypercholesterolemia: Can Atorvastatin Convert the Detrimental Effect of Hypercholesterolemia on the Immune System?

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Emruzi Zeinab; BABAHEIDARIAN PEGAH; ARSHAD MAHMOUD; Stockinger Hannes; AHANGARI GHASEM

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Journal Paper

Paper Information

Journal: Iranian Journal of Allergy, Asthma and Immunology Year:2019 | Volume:18 | Issue:5 Page(s): 554-566

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Title

Immune Modulatory Effects of Hypercholesterolemia: Can Atorvastatin Convert the Detrimental Effect of Hypercholesterolemia on the Immune System?

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Keywords

Atorvastatin

Cytokine

Hypercholesterolemia

Immune response

Abstract

Many observations showed that Hypercholesterolemia can disrupt Immune response. Statin drugs that were used for the treatment of Hypercholesterolemia patients can interfere in the regulation of the Immune response and Cytokine secretion. The primary aim of the current study was to investigate the Immune response among treatment-naï ve patients with Hypercholesterolemia and healthy subjects. The secondary goal of the study was to determine whether Atorvastatin can reverse the detrimental effect of Hypercholesterolemia on the immune system. Peripheral blood mononuclear cells (PBMCs) were isolated from 50 patients afflicted with Hypercholesterolemia who were treatment-naï ve along with 50 sex/age-matched Hypercholesterolemia patients receiving Atorvastatin, and 50 sex/age-matched healthy subjects. Quantitative PCR and ELISA methods were used for gene and protein expression analysis of T helper 1 (Th1) and Th2 related Cytokines. Additionally, the expression of the cluster of differentiation (CD) markers on T, B, and natural killer (NK) cells was measured by flow cytometry method. The results showed that Hypercholesterolemia and Atorvastatin down-regulated the expression of Th1-related Cytokines and elevated the levels of Th2-related Cytokines. The expression of cell surface markers, CD25 and CD69, was significantly decreased in the treatment-naï ve, and Atorvastatin groups. It seems that Atorvastatin is not able to repair the deleterious effects of Hypercholesterolemia on the immune system. Moreover, elevated levels of cholesterol along with the administration of Atorvastatin tilt the Th1/Th2 balance in favor of Th2 and reduce T cell activation.

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APA: Copy

Emruzi, Zeinab, BABAHEIDARIAN, PEGAH, ARSHAD, MAHMOUD, Stockinger, Hannes, & AHANGARI, GHASEM. (2019). Immune Modulatory Effects of Hypercholesterolemia: Can Atorvastatin Convert the Detrimental Effect of Hypercholesterolemia on the Immune System?. IRANIAN JOURNAL OF ALLERGY, ASTHMA AND IMMUNOLOGY (IJAAI), 18(5), 554-566. SID. https://sid.ir/paper/758420/en

Vancouver: Copy

Emruzi Zeinab, BABAHEIDARIAN PEGAH, ARSHAD MAHMOUD, Stockinger Hannes, AHANGARI GHASEM. Immune Modulatory Effects of Hypercholesterolemia: Can Atorvastatin Convert the Detrimental Effect of Hypercholesterolemia on the Immune System?. IRANIAN JOURNAL OF ALLERGY, ASTHMA AND IMMUNOLOGY (IJAAI)[Internet]. 2019;18(5):554-566. Available from: https://sid.ir/paper/758420/en

IEEE: Copy

Zeinab Emruzi, PEGAH BABAHEIDARIAN, MAHMOUD ARSHAD, Hannes Stockinger, and GHASEM AHANGARI, “Immune Modulatory Effects of Hypercholesterolemia: Can Atorvastatin Convert the Detrimental Effect of Hypercholesterolemia on the Immune System?,” IRANIAN JOURNAL OF ALLERGY, ASTHMA AND IMMUNOLOGY (IJAAI), vol. 18, no. 5, pp. 554–566, 2019, [Online]. Available: https://sid.ir/paper/758420/en

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