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Information Journal Paper

Title

Epithelial Membrane Antigen in Papillary Thyroid Carcinoma and Multinodular Goiter; a Marker of Discrimination

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  0-0

Abstract

 Background: Papillary thyroid cancer is the most common type of thyroid malignancies. For a more accurate diagnosis, Immunohistochemistry has been used widely in recent years. Epithelial Membrane Antigen has been detected in several benign and malignant lesions, and its use as a marker of malignancy has been sought in some studies. Objectives: The current study aimed to determine the presence and level of expression of Epithelial Membrane Antigen in Papillary Thyroid Carcinoma and Multinodular Goiter. Methods: Eighty-five samples of Papillary Thyroid Carcinoma and 40 cases of Multinodular Goiter were stained histochemically for Epithelial Membrane Antigen. The intensity of staining was classified in a semi-quantitative manner (1+ to 4+). Demographic data of the index cases, history of metastasis, and Lymph Node Involvement, if any, were collected as well. Results: All PTCs and 87. 5% of MNGs were positive for EMA. EMA was expressed more strongly in PTCs than in MNGs (P < 0. 00). EMA reactivity was directly associated with Lymph Node Involvement, Capsular Invasion, and size of the tumor (P = 0. 008, P < 0. 001, and P < 0. 001, respectively). The intensity level of 2 or higher had high specificity for differentiating PTC from MNG. Conclusions: Strong expression of EMA may be a good marker of malignancy in differentiating PTC from MNG. This marker may also be regarded as an index of invasive behavior of PTC.

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    APA: Copy

    Miratashi Yazdi, Seyed Amir, HESHMATI, MARJAN, & JALALI NADOUSHAN, MOHAMMADREZA. (2020). Epithelial Membrane Antigen in Papillary Thyroid Carcinoma and Multinodular Goiter; a Marker of Discrimination. IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ), 22(7), 0-0. SID. https://sid.ir/paper/758606/en

    Vancouver: Copy

    Miratashi Yazdi Seyed Amir, HESHMATI MARJAN, JALALI NADOUSHAN MOHAMMADREZA. Epithelial Membrane Antigen in Papillary Thyroid Carcinoma and Multinodular Goiter; a Marker of Discrimination. IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ)[Internet]. 2020;22(7):0-0. Available from: https://sid.ir/paper/758606/en

    IEEE: Copy

    Seyed Amir Miratashi Yazdi, MARJAN HESHMATI, and MOHAMMADREZA JALALI NADOUSHAN, “Epithelial Membrane Antigen in Papillary Thyroid Carcinoma and Multinodular Goiter; a Marker of Discrimination,” IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ), vol. 22, no. 7, pp. 0–0, 2020, [Online]. Available: https://sid.ir/paper/758606/en

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