Predictors and Conversion Rate of Clinically Isolated Syndrome to Clinically Definite Multiple Sclerosis: A Follow-up Study in Patients Living in the Southern Part of Iran

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IZADI SADEGH; Ahmadi Meysam; POURSADEGHFARD MARYAM

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Journal Paper

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Journal: Caspian Journal of Neurological Sciences Year:2020 | Volume:6 | Issue:1 (20) Page(s): 9-15

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Title

Predictors and Conversion Rate of Clinically Isolated Syndrome to Clinically Definite Multiple Sclerosis: A Follow-up Study in Patients Living in the Southern Part of Iran

Author(s)

IZADI SADEGH | Ahmadi Meysam | POURSADEGHFARD MARYAM | Issue Writer Certificate

Keywords

Multiple Sclerosis (MS)

Demyelinating disease

Risk factors

Abstract

Background: Clinical course of Clinically Isolated Syndrome (CIS) is variable, and identifying patients who will eventually develop Multiple Sclerosis (MS) is essential. Objectives: To assess the conversion rate of CIS to Clinically Definite Multiple Sclerosis (CDMS) and its predictors in southern Iran. Materials & Methods: A total of 143 CIS patients registered to Fars Multiple Sclerosis Society (FMSS) were enrolled in the study from 2006 until 2012, and all of them were followed for 5 years. Also, their demographic and MRI data were recorded. The obtained data were analyzed by univariate and multivariable Cox regression models in SPSS v. 17. P<0. 05 was considered statistically significant. Results: About 26. 6% of patients progressed to MS after a mean duration of 3. 4± 1. 1 years. The conversion rate was 27. 6% in patients presented with optic neuritis, and 25. 6% in patients presented with spinal cord problems. Although it was not statistically significant (P=0. 23), the mean age of the patients who converted to MS was lower at the onset of the presentation (27. 6 vs. 29. 4 years). In patients who had 3 or more MRI lesions, the conversion rate was 49. 2%; however, it was only 9. 8% in subjects who had fewer than 3 lesions (OR=8. 95, 95% CI=3. 69– 21. 7, P <0. 001). Women had higher conversion rate though it was not statistically significant (OR=2. 09, 95% CI=0. 57– 7. 64, P=0. 26). Conclusion: Our results supported this supposition that the number of MRI lesions at baseline can be used as a predictor of CIS conversion to MS.

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APA: Copy

IZADI, SADEGH, Ahmadi, Meysam, & POURSADEGHFARD, MARYAM. (2020). Predictors and Conversion Rate of Clinically Isolated Syndrome to Clinically Definite Multiple Sclerosis: A Follow-up Study in Patients Living in the Southern Part of Iran. CASPIAN JOURNAL OF NEUROLOGICAL SCIENCES, 6(1 (20)), 9-15. SID. https://sid.ir/paper/758634/en

Vancouver: Copy

IZADI SADEGH, Ahmadi Meysam, POURSADEGHFARD MARYAM. Predictors and Conversion Rate of Clinically Isolated Syndrome to Clinically Definite Multiple Sclerosis: A Follow-up Study in Patients Living in the Southern Part of Iran. CASPIAN JOURNAL OF NEUROLOGICAL SCIENCES[Internet]. 2020;6(1 (20)):9-15. Available from: https://sid.ir/paper/758634/en

IEEE: Copy

SADEGH IZADI, Meysam Ahmadi, and MARYAM POURSADEGHFARD, “Predictors and Conversion Rate of Clinically Isolated Syndrome to Clinically Definite Multiple Sclerosis: A Follow-up Study in Patients Living in the Southern Part of Iran,” CASPIAN JOURNAL OF NEUROLOGICAL SCIENCES, vol. 6, no. 1 (20), pp. 9–15, 2020, [Online]. Available: https://sid.ir/paper/758634/en

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