Comparison of Medroxyprogesterone Acetate With Cetrotide for Prevention of Premature Luteinizing Hormone Surges in Women Undergoing In Vitro Fertilization

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HAMDI KOBRA; FARZADI LAYA; Ghasemzadeh Alea; NAVALI NAZLI; ATASHKHOEI SIMIN; PIA HELEN; Shahnazi Vahedeh; FATTAHI AMIR; Bahrami-asl Zahra; SEPASI FARNAZ; Dopour Faliz Massomeh; Lahroudi Nahid; Hakimi Parvin

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Journal: International Journal of Women's Health and Reproduction Sciences Year:2018 | Volume:6 | Issue:2 Page(s): 187-191

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Title

Comparison of Medroxyprogesterone Acetate With Cetrotide for Prevention of Premature Luteinizing Hormone Surges in Women Undergoing In Vitro Fertilization

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Keywords

Medroxyprogesterone acetate

Controlled ovarian stimulation

Premature LH surge

Abstract

Objectives: The aim of the study was to investigate the role of Medroxyprogesterone acetate (MPA) in the prevention of luteinizing hormone (LH) surge during controlled ovarian hyperstimulation (COH). Characteristics of cycle and pregnancy outcomes were compared in subsequent frozen-thawed embryo transfer (FET) cycles. Materials and Methods: In a prospective controlled study, In vitro fertilization (IVF)/intracytoplasmic sperm injection treatment was done in 99 patients. In the case group, hMG and MPA were administered from third day of the cycle, simultaneously. As dominant follicles matured, ovulation was induced by hCG or GnRH agonist. hMG and GnRH were administrated to the control group. For later transfer in both protocols, viable embryos were cryopreserved. The primary outcome measured was the incidence of Premature LH surge and a number of oocytes retrieved. Clinical pregnancy outcomes from FETs were secondary outcomes. Results: The number of oocytes retrieved in both case and control groups were equal. LH suppression persisted during ovarian stimulation in the case group, and there was no incidence of Premature LH surge. There was no significant difference between amounts of follicles, mature follicles, oocytes resumed and obtained embryos between 2 groups (P > 0. 05). Conclusions: The results showed that in a woman undergoing COH, MPA as an oral drug was effective in the prevention of Premature LH surge. The results would help to establish a new method for ovarian stimulation in combination with embryo cryopreservation.

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APA: Copy

HAMDI, KOBRA, FARZADI, LAYA, Ghasemzadeh, Alea, NAVALI, NAZLI, ATASHKHOEI, SIMIN, PIA, HELEN, Shahnazi, Vahedeh, FATTAHI, AMIR, Bahrami-asl, Zahra, SEPASI, FARNAZ, Dopour Faliz, Massomeh, Lahroudi, Nahid, & Hakimi, Parvin. (2018). Comparison of Medroxyprogesterone Acetate With Cetrotide for Prevention of Premature Luteinizing Hormone Surges in Women Undergoing In Vitro Fertilization. INTERNATIONAL JOURNAL OF WOMEN’S HEALTH AND REPRODUCTION SCIENCES, 6(2), 187-191. SID. https://sid.ir/paper/758744/en

Vancouver: Copy

HAMDI KOBRA, FARZADI LAYA, Ghasemzadeh Alea, NAVALI NAZLI, ATASHKHOEI SIMIN, PIA HELEN, Shahnazi Vahedeh, FATTAHI AMIR, Bahrami-asl Zahra, SEPASI FARNAZ, Dopour Faliz Massomeh, Lahroudi Nahid, Hakimi Parvin. Comparison of Medroxyprogesterone Acetate With Cetrotide for Prevention of Premature Luteinizing Hormone Surges in Women Undergoing In Vitro Fertilization. INTERNATIONAL JOURNAL OF WOMEN’S HEALTH AND REPRODUCTION SCIENCES[Internet]. 2018;6(2):187-191. Available from: https://sid.ir/paper/758744/en

IEEE: Copy

KOBRA HAMDI, LAYA FARZADI, Alea Ghasemzadeh, NAZLI NAVALI, SIMIN ATASHKHOEI, HELEN PIA, Vahedeh Shahnazi, AMIR FATTAHI, Zahra Bahrami-asl, FARNAZ SEPASI, Massomeh Dopour Faliz, Nahid Lahroudi, and Parvin Hakimi, “Comparison of Medroxyprogesterone Acetate With Cetrotide for Prevention of Premature Luteinizing Hormone Surges in Women Undergoing In Vitro Fertilization,” INTERNATIONAL JOURNAL OF WOMEN’S HEALTH AND REPRODUCTION SCIENCES, vol. 6, no. 2, pp. 187–191, 2018, [Online]. Available: https://sid.ir/paper/758744/en

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