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Information Journal Paper

Title

Evaluation of BAX and BCL-2 Gene Expression Levels and Apoptosis in Resveratrol Affected Human Leukemic Cell Line: CCRF-CEM

Pages

  209-213

Abstract

 Objectives: Acute lymphoblastic Leukemia (ALL) is considered one of the common types of cancers in childhood with an incidence of up to 25%. In addition, drug resistance is a phenomenon which reduces the chances of overcoming cancer. Further, a phytoalexin combination called Resveratrol can sensitize the leukemic cells to apoptotic cell death. Due to the importance of the above-mentioned issues, the present study aimed to evaluate the effect of Resveratrol on BAX and BCL-2 expression levels and Apoptosis induction. Materials and Methods: CCRF-CEM cultured cells were treated by Resveratrol at doses of 15, 50, and 100 µ M based on previous studies. Furthermore, RT Polymerase chain reaction (PCR) was conducted to assess the BAX and BCL-2 Gene expression. Moreover, the amount of Apoptosis induction was analyzed by annexin V staining method. Results: Based on the results, time and concentration were found to play a critical role in Resveratrol-induced Apoptosis. Additionally, BAX upregulation and BCL-2 downregulation excreted by Resveratrol in CCRF-CEM cells resulted in predisposing these cells to Apoptosis. Conclusions: In general, it was revealed that Resveratrol could have a chemo-preventive activity by modifying the expression of BAX and BCL-2 Genes. Finally, Resveratrol was found to be a supplement drug in anti-leukemic therapy.

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    APA: Copy

    Pour Vahdani, Shiva, KHANZADEH, TAGHI, Karimi, Fattaneh, Jahanban Esfahlan, Aylin, Ghavipanjeh, Somayeh, GHASEMI, AMIN, ZADI HEYDARABAD, MILAD, AZIZI, HAKIM, DARBIN, AKBAR, KHORRAMI, ARASH, & Azimi, Ako. (2019). Evaluation of BAX and BCL-2 Gene Expression Levels and Apoptosis in Resveratrol Affected Human Leukemic Cell Line: CCRF-CEM. CRESCENT JOURNAL OF MEDICAL AND BIOLOGICAL SCIENCES, 6(2), 209-213. SID. https://sid.ir/paper/758829/en

    Vancouver: Copy

    Pour Vahdani Shiva, KHANZADEH TAGHI, Karimi Fattaneh, Jahanban Esfahlan Aylin, Ghavipanjeh Somayeh, GHASEMI AMIN, ZADI HEYDARABAD MILAD, AZIZI HAKIM, DARBIN AKBAR, KHORRAMI ARASH, Azimi Ako. Evaluation of BAX and BCL-2 Gene Expression Levels and Apoptosis in Resveratrol Affected Human Leukemic Cell Line: CCRF-CEM. CRESCENT JOURNAL OF MEDICAL AND BIOLOGICAL SCIENCES[Internet]. 2019;6(2):209-213. Available from: https://sid.ir/paper/758829/en

    IEEE: Copy

    Shiva Pour Vahdani, TAGHI KHANZADEH, Fattaneh Karimi, Aylin Jahanban Esfahlan, Somayeh Ghavipanjeh, AMIN GHASEMI, MILAD ZADI HEYDARABAD, HAKIM AZIZI, AKBAR DARBIN, ARASH KHORRAMI, and Ako Azimi, “Evaluation of BAX and BCL-2 Gene Expression Levels and Apoptosis in Resveratrol Affected Human Leukemic Cell Line: CCRF-CEM,” CRESCENT JOURNAL OF MEDICAL AND BIOLOGICAL SCIENCES, vol. 6, no. 2, pp. 209–213, 2019, [Online]. Available: https://sid.ir/paper/758829/en

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