EVALUATION OF EFFICACY AND SIDE EFFECTS OF FILGRASTIM VERSUS PD-GRASTIM IN PREVENTION OF NEUTROPENIA IN PATIENTS WITH NEUROBLASTOMA UNDER TREATMENT WITH OPEC CHEMOTHERAPY PROTOCOL – A COMPARATIVE STUDY

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EHSANI M.A.; ORDOUEI M.; SALAMATI P.; SHAHGHOLI E.; SOTOUDEH K.; HATAMI S.; AJAMI H.; ABOU ALGHASEMI H.

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Journal: Iranian Journal of Pediatrics Year:2006 | Volume:16 | Issue:3 Page(s): 319-324

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Title

EVALUATION OF EFFICACY AND SIDE EFFECTS OF FILGRASTIM VERSUS PD-GRASTIM IN PREVENTION OF NEUTROPENIA IN PATIENTS WITH NEUROBLASTOMA UNDER TREATMENT WITH OPEC CHEMOTHERAPY PROTOCOL – A COMPARATIVE STUDY

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Keywords

NEUROBLASTOMAQ4

GRANULOCYTE COLONY STIMULATING FACTORQ3

G-CSFQ3

FILGRASTIMQ3

PDGRASTIMQ3

Abstract

Background: The purpose of this study was to compare the efficacy and side effects of FILGRASTIM (Granulocyte, Colony Stimulating Factor [G-CSF] made by Roche, Swiss) and PD-grastim (An G-CSF Analogous made by Pooyesh Daru, IRAN) on chemotherapy related neutropenia in NEUROBLASTOMA patients.Methods: This randomized clinical trial was performed on children with NEUROBLASTOMA. The inclusion criteria were: histopathologic proven neuroblastamo, age<16 years, Stage 3 or 4, without fever and infection, Absolute neutrophil count more than 1000/μl and platelet more than 100,000/μl and OPEC chemotherapy protocol which consists of (Oncovin, Platinium, Etoposide and Cyclophosphamide). This protocol was used every 28 days for 12 courses, in each course after chemotherapy 10μg/kg G-CSF (Filgrastim or PD-grastim) was used for 4 days. Patients were assigned randomly as odd and even numbers. Odd number patients received PD-grastim in odd courses & FILGRASTIM in even courses and vice versa in even number patients. A cell blood count was taken in the beginning and in the 6, 9, 13 days of the treatment, then two times weekly until neutrophil count reached 1000 μl/dl.Findings: Eight NEUROBLASTOMA (6 males and 2 females) with mean Age 2.5 years were studied. Two cases were new and others were in the middle of their chemotherapy courses. Forty four cycles (Chemotherapy plus G-CSF) were studied which in 22 cycles FILGRASTIM and in 22 cycles PD-grastim were used. Neutropenia was found in 34 cycles. The mean time of neutropenia in FILGRASTIM group was 6.4±4.68 days and in PD-grastim group was 6.5±5.09 days. Among the 2 groups there was no significant difference in the incidence, intensity, and duration of neutropenia. All patients were discharged after 9 days without any complications or side effect.Conclusion: This study shows that there are no significant differences in the efficacy and side effects of FILGRASTIM versus PDGRASTIM in prevention of neutropenia after OPEC protocol chemotherapy treatment in stage 3& 4 NEUROBLASTOMA patients.

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APA: Copy

EHSANI, M.A., ORDOUEI, M., SALAMATI, P., SHAHGHOLI, E., SOTOUDEH, K., HATAMI, S., AJAMI, H., & ABOU ALGHASEMI, H.. (2006). EVALUATION OF EFFICACY AND SIDE EFFECTS OF FILGRASTIM VERSUS PD-GRASTIM IN PREVENTION OF NEUTROPENIA IN PATIENTS WITH NEUROBLASTOMA UNDER TREATMENT WITH OPEC CHEMOTHERAPY PROTOCOL – A COMPARATIVE STUDY. IRANIAN JOURNAL OF PEDIATRICS, 16(3), 319-324. SID. https://sid.ir/paper/75897/en

Vancouver: Copy

EHSANI M.A., ORDOUEI M., SALAMATI P., SHAHGHOLI E., SOTOUDEH K., HATAMI S., AJAMI H., ABOU ALGHASEMI H.. EVALUATION OF EFFICACY AND SIDE EFFECTS OF FILGRASTIM VERSUS PD-GRASTIM IN PREVENTION OF NEUTROPENIA IN PATIENTS WITH NEUROBLASTOMA UNDER TREATMENT WITH OPEC CHEMOTHERAPY PROTOCOL – A COMPARATIVE STUDY. IRANIAN JOURNAL OF PEDIATRICS[Internet]. 2006;16(3):319-324. Available from: https://sid.ir/paper/75897/en

IEEE: Copy

M.A. EHSANI, M. ORDOUEI, P. SALAMATI, E. SHAHGHOLI, K. SOTOUDEH, S. HATAMI, H. AJAMI, and H. ABOU ALGHASEMI, “EVALUATION OF EFFICACY AND SIDE EFFECTS OF FILGRASTIM VERSUS PD-GRASTIM IN PREVENTION OF NEUTROPENIA IN PATIENTS WITH NEUROBLASTOMA UNDER TREATMENT WITH OPEC CHEMOTHERAPY PROTOCOL – A COMPARATIVE STUDY,” IRANIAN JOURNAL OF PEDIATRICS, vol. 16, no. 3, pp. 319–324, 2006, [Online]. Available: https://sid.ir/paper/75897/en

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