Effect of Genistein and L-carnitine and Their Combination on Lipid Profile and Inflammatory Cytokines in Experimental Nephrotic Syndrome

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YOUSEFINEJAD ABBAS; SIASSI FEREYDOON; JAVANBAKHT MOHAMMAD HASSAN; MOHAMMADI HAMED; Ghaedi Ehsan; ZAREI MAHNAZ; Djalali Ehsan; DJALALI MAHMOUD

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Journal: REPORTS OF BIOCHEMISTRY AND MOLECULAR BIOLOGY Year:2018 | Volume:7 | Issue:1 Page(s): 1-8

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Title

Effect of Genistein and L-carnitine and Their Combination on Lipid Profile and Inflammatory Cytokines in Experimental Nephrotic Syndrome

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Keywords

Genistein

Hyperlipidemia

Interleukin 6

L-carnitine

Nephrotic syndrome

TNF-alpha

Abstract

Background: Nephrotic syndrome is a disorder caused by kidney damage that results in severe leakage of protein from blood into urine. Hyperlipidemia is one complication of Nephrotic syndrome. L-carnitine and Genistein can control cardiovascular diseases by causing changes in lipid metabolism and cytokine production. This study was designed to examine the effects of Genistein and L-carnitine on serum lipid and cytokine profiles in experimental Nephrotic syndrome. Methods: In this study, 50 male Sprague– Dawley rats were randomly divided into five groups of 10 animals each with similar mean body weights (300± 50 g). The five groups were NC (normal-control), PC (patientcontrol), LC (L-carnitine), G (Genistein), and LCG (L-carnitine-Genistein). Serum HDL-cholesterol (HDL) LDL-cholesterol (LDL), triglyceride, cholesterol, IL-6, and TNF-α were measured. Statistics were analyzed using SPSS 18. 0. Results: At the end of the study, of the patient groups, HDL was significantly greater in the LC than in the PC or G groups (P<0. 001). LDL was significantly less in the G than in the PC, LC, or LCG groups (P<0. 001). Interleukin-6 was significantly greater in the PC than in the LC, G, or LCG groups, and significantly greater in the LC than in the G group. (P<0. 001), but no significant differences were found for triglyceride, cholesterol, or TNF-α between the patient groups. Conclusions: Genistein had less effect on HDL and triglyceride levels than LC or LCG. Regarding inflammatory cytokines, Genistein and L-carnitine had less effect on TNF-α than on IL-6.

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APA: Copy

YOUSEFINEJAD, ABBAS, SIASSI, FEREYDOON, JAVANBAKHT, MOHAMMAD HASSAN, MOHAMMADI, HAMED, Ghaedi, Ehsan, ZAREI, MAHNAZ, Djalali, Ehsan, & DJALALI, MAHMOUD. (2018). Effect of Genistein and L-carnitine and Their Combination on Lipid Profile and Inflammatory Cytokines in Experimental Nephrotic Syndrome. REPORTS OF BIOCHEMISTRY AND MOLECULAR BIOLOGY, 7(1), 1-8. SID. https://sid.ir/paper/759694/en

Vancouver: Copy

YOUSEFINEJAD ABBAS, SIASSI FEREYDOON, JAVANBAKHT MOHAMMAD HASSAN, MOHAMMADI HAMED, Ghaedi Ehsan, ZAREI MAHNAZ, Djalali Ehsan, DJALALI MAHMOUD. Effect of Genistein and L-carnitine and Their Combination on Lipid Profile and Inflammatory Cytokines in Experimental Nephrotic Syndrome. REPORTS OF BIOCHEMISTRY AND MOLECULAR BIOLOGY[Internet]. 2018;7(1):1-8. Available from: https://sid.ir/paper/759694/en

IEEE: Copy

ABBAS YOUSEFINEJAD, FEREYDOON SIASSI, MOHAMMAD HASSAN JAVANBAKHT, HAMED MOHAMMADI, Ehsan Ghaedi, MAHNAZ ZAREI, Ehsan Djalali, and MAHMOUD DJALALI, “Effect of Genistein and L-carnitine and Their Combination on Lipid Profile and Inflammatory Cytokines in Experimental Nephrotic Syndrome,” REPORTS OF BIOCHEMISTRY AND MOLECULAR BIOLOGY, vol. 7, no. 1, pp. 1–8, 2018, [Online]. Available: https://sid.ir/paper/759694/en

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