Mumijo Protection gainst Acetaminophen-Induced Acute Hepatic Injury: Role of Oxidative Stress

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Atashbar Jabber; SHAHROKHI NADER; KHAKSARI HADDAD MOHAMMAD; ASADI KARAM GHOLAMREZA; Shahrokhi Nava; GHAZI FARHOOD

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Journal: Journal of Kerman University of Medical Sciences Year:2018 | Volume:25 | Issue:1 Page(s): 44-56

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Title

Mumijo Protection gainst Acetaminophen-Induced Acute Hepatic Injury: Role of Oxidative Stress

Author(s)

Keywords

Acetaminophen

Mumijo

Liver

oxidative stress

Abstract

Background: A majority of people widely use Acetaminophen as a sedative. Overusing the drug for prolonged periods of time can lead to acute Liver damage. Mumijo, as a strong antioxidant and anti-inflammatory drug, could possibly reduce some of the Acetaminophen-induced side effects on the Liver. Thus, the aim of this study is to evaluate the effect of Mumijo on the Liver damage caused by the use of Acetaminophen. Methods: 40 male Wistar rats were randomly divided into five groups: sham, Acetaminophen, low and high doses of Mumijo, and vehicle. All groups except the sham group received a single dose of 500 mg/kg Acetaminophen via ip injection. Then the groups that were under treatment received 150 mg/kg (low dose) and 250 mg/kg (high dose) of Mumijo, and the vehicle group received distilled water as vehicle. After 24 hours, blood samples were taken for biochemical tests, and a part of the Liver was extracted for histopathological examination. Results: Acetaminophen increases the activities of functional Liver enzymes including alanine amino transferase (ALT), aspartate aminotransferase (AST), and gamma glutamine transferase (GGT). In groups under treatment, values of the mentioned enzymes were significantly reduced in comparison with the Acetaminophen and vehicle groups (P <0. 05), and on the other hand, malondialdehyde (MDA), nitric oxide (NO), and protein carbonyl (PC) increase caused by Acetaminophen were reduced by Mumijo. Furthermore, the amount of glutathione (GPX) was increased by Mumijo (P <0. 05). From a histopathological point of view, necrosis and Liver damage caused by Acetaminophen was decreased by Mumijo. Conclusion: The findings showed that Mumijo is salient in preventing Liver damage caused by consumption of high doses of Acetaminophen probably through reducing oxidant activities and also through increasing anti-inflammatory and antioxidant activities.

Cites

Health Beneficial Effects of Moomiaii in Traditional Medicine (review Article)

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APA: Copy

Atashbar, Jabber, SHAHROKHI, NADER, KHAKSARI HADDAD, MOHAMMAD, ASADI KARAM, GHOLAMREZA, Shahrokhi, Nava, & GHAZI, FARHOOD. (2018). Mumijo Protection gainst Acetaminophen-Induced Acute Hepatic Injury: Role of Oxidative Stress. JOURNAL OF KERMAN UNIVERSITY OF MEDICAL SCIENCES, 25(1), 44-56. SID. https://sid.ir/paper/759722/en

Vancouver: Copy

Atashbar Jabber, SHAHROKHI NADER, KHAKSARI HADDAD MOHAMMAD, ASADI KARAM GHOLAMREZA, Shahrokhi Nava, GHAZI FARHOOD. Mumijo Protection gainst Acetaminophen-Induced Acute Hepatic Injury: Role of Oxidative Stress. JOURNAL OF KERMAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2018;25(1):44-56. Available from: https://sid.ir/paper/759722/en

IEEE: Copy

Jabber Atashbar, NADER SHAHROKHI, MOHAMMAD KHAKSARI HADDAD, GHOLAMREZA ASADI KARAM, Nava Shahrokhi, and FARHOOD GHAZI, “Mumijo Protection gainst Acetaminophen-Induced Acute Hepatic Injury: Role of Oxidative Stress,” JOURNAL OF KERMAN UNIVERSITY OF MEDICAL SCIENCES, vol. 25, no. 1, pp. 44–56, 2018, [Online]. Available: https://sid.ir/paper/759722/en

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