Effect of Conditioned Medium from IGF1-Induced Human Wharton’ s Jelly Mesenchymal Stem Cells (IGF1-hWJMSCs-CM) on Osteoarthritis

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WIDYA KUSUMA HANNA SARI; WIDOWATI WAHYU; Gunanegara Rimonta Febby; Juliandi Berry; Lister Nyoman Ehrich; Arumwardana Seila; Yusepany Dewani Tediana; Artie Dwi Surya; Nataya Enden Dea; Gunawan Kamila Yashfa; Sholihah Ika Adhani; Girsang Ermi; Ginting Chrismis Novalinda; Bachtiar Indra; Murti Harry

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Journal: Avicenna Journal of Medical Biotechnology Year:2020 | Volume:12 | Issue:3 Page(s): 172-178

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Title

Effect of Conditioned Medium from IGF1-Induced Human Wharton’ s Jelly Mesenchymal Stem Cells (IGF1-hWJMSCs-CM) on Osteoarthritis

Author(s)

Keywords

Chondrocyte

IGF1

Osteoarthritis

Proinflammatory

Wharton’s jelly

Abstract

Background: Osteoarthritis (OA) is a chronic disease that attacks joints and bones which can be caused by trauma or other joint diseases. Stem cell and Conditioned Medium (CM) of stem cells are developed for OA therapy, which is minimally invasive. It can decrease inflammation and be a replacement for knee surgery. This study aimed to utilize human Wharton’ s Jelly-Mesenchymal Stem Cells (hWJMSCs) as an alternative OA therapy. Methods: CM from hWJMSCs induced by IGF1 was collected. The OA cells model (IL1β-CHON002) culture was treated as follows: 1) with hWJMSCs-CM 15% (v/v); 2) with hWJMSCs-CM 30% (v/v); 3) with IGF1-hWJMSCs (IGF1-hWJMSCs-CM) 15% (v/v); 4) with IGF1-hWJMSCs-CM 30% (v/v). Parameters including inflammatory cytokines (IL10 and TNFα ), extracellular matrix degradation (MMP3 expression), and chondrogenic marker (COL2 expression) were determined. Results: The most significant increase in COL2 chondrogenic markers was found in IL1β-CHON002 treatment using 15% CM of hWJMSCs induced with IGF1. CM of hWJMSCs can reduce inflammatory cytokines (TNFα and IL10) and matrix degradation mediator MMP3. Better result was gained from IGF1-induced hWJMSCs-CM. Conclusion: CM of IGF1-hWJMSCs reduce inflammation while repairing injured joint in the human Chondrocyte OA model.

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APA: Copy

WIDYA KUSUMA, HANNA SARI, WIDOWATI, WAHYU, Gunanegara, Rimonta Febby, Juliandi, Berry, Lister, Nyoman Ehrich, Arumwardana, Seila, Yusepany, Dewani Tediana, Artie, Dwi Surya, Nataya, Enden Dea, Gunawan, Kamila Yashfa, Sholihah, Ika Adhani, Girsang, Ermi, Ginting, Chrismis Novalinda, Bachtiar, Indra, & Murti, Harry. (2020). Effect of Conditioned Medium from IGF1-Induced Human Wharton’ s Jelly Mesenchymal Stem Cells (IGF1-hWJMSCs-CM) on Osteoarthritis. AVICENNA JOURNAL OF MEDICAL BIOTECHNOLOGY (AJMB), 12(3), 172-178. SID. https://sid.ir/paper/759846/en

Vancouver: Copy

WIDYA KUSUMA HANNA SARI, WIDOWATI WAHYU, Gunanegara Rimonta Febby, Juliandi Berry, Lister Nyoman Ehrich, Arumwardana Seila, Yusepany Dewani Tediana, Artie Dwi Surya, Nataya Enden Dea, Gunawan Kamila Yashfa, Sholihah Ika Adhani, Girsang Ermi, Ginting Chrismis Novalinda, Bachtiar Indra, Murti Harry. Effect of Conditioned Medium from IGF1-Induced Human Wharton’ s Jelly Mesenchymal Stem Cells (IGF1-hWJMSCs-CM) on Osteoarthritis. AVICENNA JOURNAL OF MEDICAL BIOTECHNOLOGY (AJMB)[Internet]. 2020;12(3):172-178. Available from: https://sid.ir/paper/759846/en

IEEE: Copy

HANNA SARI WIDYA KUSUMA, WAHYU WIDOWATI, Rimonta Febby Gunanegara, Berry Juliandi, Nyoman Ehrich Lister, Seila Arumwardana, Dewani Tediana Yusepany, Dwi Surya Artie, Enden Dea Nataya, Kamila Yashfa Gunawan, Ika Adhani Sholihah, Ermi Girsang, Chrismis Novalinda Ginting, Indra Bachtiar, and Harry Murti, “Effect of Conditioned Medium from IGF1-Induced Human Wharton’ s Jelly Mesenchymal Stem Cells (IGF1-hWJMSCs-CM) on Osteoarthritis,” AVICENNA JOURNAL OF MEDICAL BIOTECHNOLOGY (AJMB), vol. 12, no. 3, pp. 172–178, 2020, [Online]. Available: https://sid.ir/paper/759846/en

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