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Information Journal Paper

Title

Correlation of coronary artery calcium score and carotid artery intima-media thickness with severity of coronary artery disease

Pages

  78-83

Abstract

 Introduction: Coronary Artery Calcium Score (CACS) and Carotid Artery Intima-Media Thickness (CIMT) are the markers of atherosclerosis. An association between CACS and CIMT with presence of atherosclerotic Coronary Artery Disease (CAD) is well established. However relationship between severity of CAD with CACS and CIMT is less clear. This study aimed to investigate the correlation between severity of CAD assessed by SYNTAX and Gensini scores with CACS and CIMT. Methods: This prospective study was conducted on 351 patients with CAD between June 2015 to December 2016. CACS was obtained using AGATSTON algorithm with 128 slice multidetector computer tomography (MDCT) before conventional coronary angiography (CCA). CIMT was measured by using Philips IE33 Echo machine. The severity of CAD was assessed by SYNTAX score (SS) and Gensini score on CCA. Correlation between severity of CAD with CACS and CIMT was analysed. Results: Mean CACS was 241. 5± 463. 7, and this was positively correlated with over all SS (r=0. 417, P < 0. 0001) and Gensini score (r=0. 405, P < 0. 0001). Mean CIMT was 0. 80± 0. 18 mm and this was also significantly correlated with SS (r=0. 450, P < 0. 0001) and Gensini score (r=0. 459, P < 0. 0001). Multivariate analysis showed that CACS was independently associated with diabetes mellitus (β : 0. 11, P = 0. 021), SS (β : 0. 251, P = 0. 010) and mean CIMT (β : 0. 128, P = 0. 028). Receiver-operating characteristic (ROC) curve analysis revealed a cut off CACS of >493 for SS≥ 33 (high-SS tertile). Conclusion: Our study confirmed a significant correlation between CACS and CIMT with the severity of CAD assessed by SS and Gensini scores. CACS and CIMT may be considered as important noninvasive diagnostic modalities in the assessment of the severity of CAD.

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    APA: Copy

    Pathakota, Sudhakar Reddy, Durgaprasad, Rajasekhar, Velam, Vanajakshamma, AY, Lakshmi, & Kasala, Latheef. (2020). Correlation of coronary artery calcium score and carotid artery intima-media thickness with severity of coronary artery disease. JOURNAL OF CARDIOVASCULAR AND THORACIC RESEARCH, 12(2), 78-83. SID. https://sid.ir/paper/760000/en

    Vancouver: Copy

    Pathakota Sudhakar Reddy, Durgaprasad Rajasekhar, Velam Vanajakshamma, AY Lakshmi, Kasala Latheef. Correlation of coronary artery calcium score and carotid artery intima-media thickness with severity of coronary artery disease. JOURNAL OF CARDIOVASCULAR AND THORACIC RESEARCH[Internet]. 2020;12(2):78-83. Available from: https://sid.ir/paper/760000/en

    IEEE: Copy

    Sudhakar Reddy Pathakota, Rajasekhar Durgaprasad, Vanajakshamma Velam, Lakshmi AY, and Latheef Kasala, “Correlation of coronary artery calcium score and carotid artery intima-media thickness with severity of coronary artery disease,” JOURNAL OF CARDIOVASCULAR AND THORACIC RESEARCH, vol. 12, no. 2, pp. 78–83, 2020, [Online]. Available: https://sid.ir/paper/760000/en

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