Anti-varicella Zoster Virus IgG and hsCRP Levels Correlate with Progression of Coronary Artery Atherosclerosis

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Fouladseresht Hamed; Ghamar Talepoor Atefe; FARJADIAN SHIRIN; KHOSROPANAH SHAHDAD; DOROUDCHI MEHRNOOSH

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Journal: Iranian Journal of Allergy, Asthma and Immunology Year:2019 | Volume:18 | Issue:5 Page(s): 543-553

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Title

Anti-varicella Zoster Virus IgG and hsCRP Levels Correlate with Progression of Coronary Artery Atherosclerosis

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Keywords

Atherosclerosis

C-reactive protein

Immunoglobulin G

Varicella-zoster virus Corresponding Author:

Abstract

The relationship between high levels of anti-Varicella Zoster Virus (VZV) IgG in cerebrospinal fluid (CSF) and cerebrovascular Atherosclerosis commends a possible similar association in other vessels. We aimed to investigate the association of VZV-seropositivity with coronary artery Atherosclerosis. We recruited 88 newly diagnosed patients with more than 50% stenosis in at least one of the main coronary arteries. As the control group, 99 age-matched individuals with normal/insignificant coronary artery findings were included. Clinical, paraclinical, and demographical data were gathered at the time of sampling. High‐ sensitivity C‐ reactive protein (hsCRP) levels were measured by nephelometry. VZV-seropositivity was determined by measuring of anti-VZV IgG level in plasma. Multivariable logistic regression was used to evaluate the correlation of data with coronary vascular Atherosclerosis. The frequency of VZV-seropositivity was significantly higher in the Atherosclerosis group compared to the controls (OR=1. 88; 95%CI=1. 03-3. 44). The plasma levels of anti-VZV IgG were significantly higher in patients with Atherosclerosis (Median=2. 70, IQR=1. 53-4. 30 AU/mL) than in the controls (Median=2. 10, IQR=1. 70-3. 10 AU/mL, p=0. 034). The hsCRP levels in patients and controls were 5. 19± 2. 00 and 1. 51± 1. 07 mg/L, respectively. The correlation between hsCRP and anti-VZV IgG level in plasma was observed (r=0. 40, p<0. 001). The levels of hsCRP and anti-VZV IgG increased based on the number of diseased vessels but only the difference in hsCRP levels reached a significant level (p<0. 001 and p=0. 168, respectively). Our data suggest that VZV-seropositivity and hsCRP elevation jointly increase the risk of Atherosclerosis. The multifactorial nature of Atherosclerosis; however, leaves more options for the inflammatory milieu to be generated.

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APA: Copy

Fouladseresht, Hamed, Ghamar Talepoor, Atefe, FARJADIAN, SHIRIN, KHOSROPANAH, SHAHDAD, & DOROUDCHI, MEHRNOOSH. (2019). Anti-varicella Zoster Virus IgG and hsCRP Levels Correlate with Progression of Coronary Artery Atherosclerosis. IRANIAN JOURNAL OF ALLERGY, ASTHMA AND IMMUNOLOGY (IJAAI), 18(5), 543-553. SID. https://sid.ir/paper/760237/en

Vancouver: Copy

Fouladseresht Hamed, Ghamar Talepoor Atefe, FARJADIAN SHIRIN, KHOSROPANAH SHAHDAD, DOROUDCHI MEHRNOOSH. Anti-varicella Zoster Virus IgG and hsCRP Levels Correlate with Progression of Coronary Artery Atherosclerosis. IRANIAN JOURNAL OF ALLERGY, ASTHMA AND IMMUNOLOGY (IJAAI)[Internet]. 2019;18(5):543-553. Available from: https://sid.ir/paper/760237/en

IEEE: Copy

Hamed Fouladseresht, Atefe Ghamar Talepoor, SHIRIN FARJADIAN, SHAHDAD KHOSROPANAH, and MEHRNOOSH DOROUDCHI, “Anti-varicella Zoster Virus IgG and hsCRP Levels Correlate with Progression of Coronary Artery Atherosclerosis,” IRANIAN JOURNAL OF ALLERGY, ASTHMA AND IMMUNOLOGY (IJAAI), vol. 18, no. 5, pp. 543–553, 2019, [Online]. Available: https://sid.ir/paper/760237/en

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