Tumorigenicity of Esophageal Cancer Stem Cells (ECSCs) in nude mouse xenograft model

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

KHOSRAVI AYYOOB; Kokabi Fariba; Behzadi Ramezan; ASADI JAHANBAKHSH

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: JORJANI BIOMEDICINE JOURNAL Year:2019 | Volume:7 | Issue:3 Page(s): 4-10

Download Full-Text

View:

106

Download:

110

Cites:

Information Journal Paper

Title

Tumorigenicity of Esophageal Cancer Stem Cells (ECSCs) in nude mouse xenograft model

Author(s)

KHOSRAVI AYYOOB | Kokabi Fariba | Behzadi Ramezan | ASADI JAHANBAKHSH | Issue Writer Certificate

Keywords

Cancer stem cell

ESCC

Xenograft mouse model

Abstract

Background and objectives: Modeling cancer in vivo is a very important tool to investigate cancer pathogenesis and molecular mechanisms involved in cancer progression. Laboratory mice are the most common animal used for rebuilding human cancer in vivo. Cancer stem cells (CSCs) are the main reason of failure in cancer therapy because of tumor relapse and metastasis. Isolation of Cancer stem cells helps us to study their function and behavior. In the current study we separate cancer stem-like cells using sphere formation assay then investigate their tumorigenicity in xenograft tumor model. Methods: YM1 cancer cells were cultured in serum-free media (SFM) in low adherent culture dishes for enrichment of Cancer stem cells. The resulting spheres containing cancer stem-like cells were dissociated into single cells and were injected into the dorsal flank of B6 nude mice. Results: A few days after injection, subcutaneous tumors formed. The growth curves of the resulting tumors were plotted using their weekly recorded lengths. The tumors' volume and weight were measured. The size of resulting tumors was appropriate to the number of cells injected. Pathological analysis confirmed esophageal origin of the resulting tumors. Conclusion: Using laboratory mice models is a practical modeling system that provides us investigation of human tumors pathogenesis in vivo.

Cites

No record.

References

No record.

Cite

APA: Copy

KHOSRAVI, AYYOOB, Kokabi, Fariba, Behzadi, Ramezan, & ASADI, JAHANBAKHSH. (2019). Tumorigenicity of Esophageal Cancer Stem Cells (ECSCs) in nude mouse xenograft model. JORJANI BIOMEDICINE JOURNAL, 7(3), 4-10. SID. https://sid.ir/paper/760653/en

Vancouver: Copy

KHOSRAVI AYYOOB, Kokabi Fariba, Behzadi Ramezan, ASADI JAHANBAKHSH. Tumorigenicity of Esophageal Cancer Stem Cells (ECSCs) in nude mouse xenograft model. JORJANI BIOMEDICINE JOURNAL[Internet]. 2019;7(3):4-10. Available from: https://sid.ir/paper/760653/en

IEEE: Copy

AYYOOB KHOSRAVI, Fariba Kokabi, Ramezan Behzadi, and JAHANBAKHSH ASADI, “Tumorigenicity of Esophageal Cancer Stem Cells (ECSCs) in nude mouse xenograft model,” JORJANI BIOMEDICINE JOURNAL, vol. 7, no. 3, pp. 4–10, 2019, [Online]. Available: https://sid.ir/paper/760653/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops