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Concomitant Serum Presence of Hepatitis B Surface Antigen (HBsAg) and High Titers of Hepatitis B Surface Antibodies (Anti-HBsAb) in a Patient with Chronic Hepatitis B (HBV) Genotype D from Black Sea Coast Region: A Case Report

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Abstract

 Introduction: Hepatitis B Virus genotypes influence Chronic Hepatitis B evolution and show geographic preferences. In Eastern Europe, HBV-D genotype seems to be dominant, still, without enough information regarding the prevalence of its four subtypes. In addition, treatment with Nucleos(t)ide Analogues (NUCs) has lower impact on HBV-D genotype clearance compared to others. This study aimed at presenting the case of a middle age female diagnosed, followed-up and treated for eight years with entecavir 0. 5 mg/day, in whom an increase of anti-HBsAb titer was noted over the immunogenicity level and undetectable viremia, despite the continuous presence of HBsAg. This is an uncommon type of evolution, most patients with anti-HBsAb over 10 IU/mL show seroconversion in the “ s” system in a few months. Case Presentation: The researchers used the COBAS TaqMan HBV Monitor Test (Roche Diagnostics, Branchburg, NJ) in order to measure serum HBV DNA level, then, the viral DNA was extracted from 200  L of serum using QIAamp DNA blood mini kit (Qiagen, Germany). The amplification and sequencing of full DNA length was done by the Rolling Circle Amplification (RCA) technique. Hepatitis B Virus genotype was determined using the NCBI genotyping tool and phylogenetic analysis. Conclusions: The patient was proved to haveDgenotype. TheDNAanalyzes showed escape mutations in the “ a” determinant within the S gene, represented by sQ129R, respectively, sI134T, reported by the literature in a small number of C genotype patients. The paradoxical serum profile of the current patient with positive HBsAg, increased titers of anti-HBsAb, and undetectable viral load could be a possible model of evolution for D genotype HBV chronic infected patients treated with NUCs, cohort genetic studies on patients with the same serum profile are required to confirm this pattern of evolution.

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    APA: Copy

    Suceveanu, Andra Iulia, Mazilu, Laura, Voinea, Claudia, & Suceveanu, Adrian Paul. (2018). Concomitant Serum Presence of Hepatitis B Surface Antigen (HBsAg) and High Titers of Hepatitis B Surface Antibodies (Anti-HBsAb) in a Patient with Chronic Hepatitis B (HBV) Genotype D from Black Sea Coast Region: A Case Report. HEPATITIS MONTHLY, 18(5), 0-0. SID. https://sid.ir/paper/761252/en

    Vancouver: Copy

    Suceveanu Andra Iulia, Mazilu Laura, Voinea Claudia, Suceveanu Adrian Paul. Concomitant Serum Presence of Hepatitis B Surface Antigen (HBsAg) and High Titers of Hepatitis B Surface Antibodies (Anti-HBsAb) in a Patient with Chronic Hepatitis B (HBV) Genotype D from Black Sea Coast Region: A Case Report. HEPATITIS MONTHLY[Internet]. 2018;18(5):0-0. Available from: https://sid.ir/paper/761252/en

    IEEE: Copy

    Andra Iulia Suceveanu, Laura Mazilu, Claudia Voinea, and Adrian Paul Suceveanu, “Concomitant Serum Presence of Hepatitis B Surface Antigen (HBsAg) and High Titers of Hepatitis B Surface Antibodies (Anti-HBsAb) in a Patient with Chronic Hepatitis B (HBV) Genotype D from Black Sea Coast Region: A Case Report,” HEPATITIS MONTHLY, vol. 18, no. 5, pp. 0–0, 2018, [Online]. Available: https://sid.ir/paper/761252/en

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