Evaluation of the Possible Synergic Regenerative Effects of Platelet-Rich Plasma and Hydroxyapatite/Zirconia in the Rabbit Mandible Defect Model

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Shahsavari Pour Sheila; Aliabadi Ehsan; Latifi Mona; Zareifard Nehle; NAMAVAR MOHAMMAD REZA; TALAEI KHOZANI TAHEREH

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Journal: IRANIAN JOURNAL OF MEDICAL SCIENCES (IJMS) Year:2018 | Volume:43 | Issue:6 Page(s): 633-644

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Title

Evaluation of the Possible Synergic Regenerative Effects of Platelet-Rich Plasma and Hydroxyapatite/Zirconia in the Rabbit Mandible Defect Model

Author(s)

Keywords

Durapatite

Hydroxyapatite

Zirconium oxide

Platelet-Rich plasma

Heparan sulfate proteoglycans

Osteogenesis

Abstract

Background: Platelet-Rich plasma (PRP) and bioceramics such as Hydroxyapatite (HA) and Zirconium oxide (ZrO2) are used to reconstruct mandibular defects. We sought to determine the synergistic effects of HA/ZrO2 and PRP and compare their osteogenic activity. Methods: ZrO2 scaffolds were constructed by the slurry method and were then coated with HA and impregnated by PRP/ heparan sulfate (HS). Bilateral mandibular defects were created in 26 male rabbits. In 20 rabbits, the left defects were treated with HA/ZrO2/PRP (Group 1) and the corresponding right defects were filled with HA/ZrO2 (Group 2). The 6 remaining models were treated with PRP gels at both sides (Group 3). The osteoconductivity of HA/ZrO2/PRP was compared with that of HA/ZrO2 or PRP by radiological and histological methods after the follow-up period, at weeks 2, 6 and 8. The statistical analyses were performed by ANOVA and LSD using SPSS, version 16. 0, for Windows (P<0. 05). Results: After 2 weeks, the percentage of the surface occupied by bone was significantly higher in the HA/ZrO2/PRP-treated defects than in the PRP-treated defects (P=0. 007). Osteoblast and osteocyte counts were higher significantly in the PRPtreated group (P=0. 032); however, the cells had not started matrix formation on a large scale and just small islands of osteoid with trapped osteocytes were observed. In the long term, the regenerative potential of all the scaffolds was the same. Conclusion: HA/ZrO2 showed a superior osteoconductive capacity over PRP in the short term; however, they showed no long-term synergic effects.

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APA: Copy

Shahsavari Pour, Sheila, Aliabadi, Ehsan, Latifi, Mona, Zareifard, Nehle, NAMAVAR, MOHAMMAD REZA, & TALAEI KHOZANI, TAHEREH. (2018). Evaluation of the Possible Synergic Regenerative Effects of Platelet-Rich Plasma and Hydroxyapatite/Zirconia in the Rabbit Mandible Defect Model. IRANIAN JOURNAL OF MEDICAL SCIENCES (IJMS), 43(6), 633-644. SID. https://sid.ir/paper/761605/en

Vancouver: Copy

Shahsavari Pour Sheila, Aliabadi Ehsan, Latifi Mona, Zareifard Nehle, NAMAVAR MOHAMMAD REZA, TALAEI KHOZANI TAHEREH. Evaluation of the Possible Synergic Regenerative Effects of Platelet-Rich Plasma and Hydroxyapatite/Zirconia in the Rabbit Mandible Defect Model. IRANIAN JOURNAL OF MEDICAL SCIENCES (IJMS)[Internet]. 2018;43(6):633-644. Available from: https://sid.ir/paper/761605/en

IEEE: Copy

Sheila Shahsavari Pour, Ehsan Aliabadi, Mona Latifi, Nehle Zareifard, MOHAMMAD REZA NAMAVAR, and TAHEREH TALAEI KHOZANI, “Evaluation of the Possible Synergic Regenerative Effects of Platelet-Rich Plasma and Hydroxyapatite/Zirconia in the Rabbit Mandible Defect Model,” IRANIAN JOURNAL OF MEDICAL SCIENCES (IJMS), vol. 43, no. 6, pp. 633–644, 2018, [Online]. Available: https://sid.ir/paper/761605/en

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