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Information Journal Paper

Title

Potential Effect of Simvastatin as an Anti-Cancer Agent on SOX7 and SOX9 Expression in Prostate Cancer Cell Lines

Pages

  0-0

Keywords

PC3 

Abstract

 Background: Prostate cancer (PCa) is the second leading cause of cancer death in men, worldwide. Geranylgeranylation and farnesylation have a main role in the carcinogenic process, which can be prevented via statins as HMGCOA reductase enzyme inhibitors in cholesterol biosynthesis. These effects might be controlled by several transcription factors such as SOX7 and SOX9, which have been involved in PCa initiation and progression. To the best of our knowledge, no study has demonstrated the association of Simvastatin and SOX status in PCa. Therefore, this study is an attempt to evaluate whether Simvastatin induces anti-neoplastic effects via the SOX9 and SOX7 transcription factors. Methods: Prostate cancer cell lines LNCaP and PC3 were used to evaluate the expression of SOX7 and SOX9 using quantitative RT-PCR. Results: Our data was analyzed by applying one-way ANOVA and Tukey’ s test and determined that 0. 07  Mof Simvastatin after 24 h was sufficient to upregulate SOX7 mRNA expression ratio by 3. 58 fold in LNCaP. In addition, the level of SOX9 mRNA expression was increased by 12. 18 fold at 0. 07  M after 24 h, 8. 67 fold at 0. 001  M after 24 h, and 6. 33 fold at 0. 07  M after 12 h in LNCaP and in PC3 cell line. The level of SOX9 mRNA expression was increased by 2. 64 fold at 0. 5  Mafter 24 h and 2. 78 fold at 0. 1  Mafter 12 h, however, it decreased by 0. 67 fold at 0. 1  Mafter 24 h. Conclusions: Our findings suggest that Simvastatin can induce the anti-cancer properties via manipulating the expression of SOX7 in LNCaP, as the androgen-dependent cell.

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    APA: Copy

    Arabizadeh, Elham, Mostafavipour, Zohreh, KAVOUSIPOUR, SOUDABEH, Saeb, Saeedeh, MOKARRAM, POONEH, & GHAVAMI, SAEID. (2019). Potential Effect of Simvastatin as an Anti-Cancer Agent on SOX7 and SOX9 Expression in Prostate Cancer Cell Lines. SHIRAZ E MEDICAL JOURNAL, 20(2), 0-0. SID. https://sid.ir/paper/761620/en

    Vancouver: Copy

    Arabizadeh Elham, Mostafavipour Zohreh, KAVOUSIPOUR SOUDABEH, Saeb Saeedeh, MOKARRAM POONEH, GHAVAMI SAEID. Potential Effect of Simvastatin as an Anti-Cancer Agent on SOX7 and SOX9 Expression in Prostate Cancer Cell Lines. SHIRAZ E MEDICAL JOURNAL[Internet]. 2019;20(2):0-0. Available from: https://sid.ir/paper/761620/en

    IEEE: Copy

    Elham Arabizadeh, Zohreh Mostafavipour, SOUDABEH KAVOUSIPOUR, Saeedeh Saeb, POONEH MOKARRAM, and SAEID GHAVAMI, “Potential Effect of Simvastatin as an Anti-Cancer Agent on SOX7 and SOX9 Expression in Prostate Cancer Cell Lines,” SHIRAZ E MEDICAL JOURNAL, vol. 20, no. 2, pp. 0–0, 2019, [Online]. Available: https://sid.ir/paper/761620/en

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