A Randomized Control Trial Study to Determine the Effect of Melatonin on Serum Levels of IL-1β and TNF-α in Patients with Multiple Sclerosis

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Yosefifard Masoomeh; VAEZI GHOLAM HASSAN; MALEKIRAD ALI AKBAR; FARAJI FARDIN; HOJATI VIDA

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Journal: Iranian Journal of Allergy, Asthma and Immunology Year:2019 | Volume:18 | Issue:6 Page(s): 649-654

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Title

A Randomized Control Trial Study to Determine the Effect of Melatonin on Serum Levels of IL-1β and TNF-α in Patients with Multiple Sclerosis

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Keywords

Interleukin 1 beta

Multiple sclerosis

Melatonin

Tumor necrosis factor-alpha

Abstract

Multiple sclerosis (MS) is the most common neurological disease that happens at a young age. MS is an inflammatory disease; associated with the demyelination of the central nervous system. Therefore, some inflammatory factors are effective in the mechanism and progression of the disease. Melatonin, as a multi-effect substance including anti-inflammatory effects, can reduce symptoms of MS in patients with a change in their inflammatory factors level. In this study, 50 MS patients who were referred to the MS Society of Markazi Province were randomly selected. All patients were treated with routine MS treatment (interferon) and were divided into control (25 placebo recipients) and treatment (25 recipients of 3 mg Melatonin per day for 24 weeks) groups. Anthropometric data of patients including height, weight, and age were determined. Blood samples were collected after fasting in order to determine serum levels of Interleukin 1 beta (IL-1β ) and Tumor necrosis factor-alpha (TNF-α ). Then, samples were immediately centrifuged for serum separation and sera were transferred to a freezer at-80° C and serum levels of these factors were determined; using ELISA kit. The results of this study showed that there was no significant difference between the control and treatment groups in terms of serum levels of TNF-α . However, the level of IL-1β was significantly reduced in the treatment group compared to the control group, indicating that Melatonin decreases this inflammatory substance. Our findings suggest a valuable strategy in the treatment of patients who suffer from MS.

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APA: Copy

Yosefifard, Masoomeh, VAEZI, GHOLAM HASSAN, MALEKIRAD, ALI AKBAR, FARAJI, FARDIN, & HOJATI, VIDA. (2019). A Randomized Control Trial Study to Determine the Effect of Melatonin on Serum Levels of IL-1β and TNF-α in Patients with Multiple Sclerosis. IRANIAN JOURNAL OF ALLERGY, ASTHMA AND IMMUNOLOGY (IJAAI), 18(6), 649-654. SID. https://sid.ir/paper/761624/en

Vancouver: Copy

Yosefifard Masoomeh, VAEZI GHOLAM HASSAN, MALEKIRAD ALI AKBAR, FARAJI FARDIN, HOJATI VIDA. A Randomized Control Trial Study to Determine the Effect of Melatonin on Serum Levels of IL-1β and TNF-α in Patients with Multiple Sclerosis. IRANIAN JOURNAL OF ALLERGY, ASTHMA AND IMMUNOLOGY (IJAAI)[Internet]. 2019;18(6):649-654. Available from: https://sid.ir/paper/761624/en

IEEE: Copy

Masoomeh Yosefifard, GHOLAM HASSAN VAEZI, ALI AKBAR MALEKIRAD, FARDIN FARAJI, and VIDA HOJATI, “A Randomized Control Trial Study to Determine the Effect of Melatonin on Serum Levels of IL-1β and TNF-α in Patients with Multiple Sclerosis,” IRANIAN JOURNAL OF ALLERGY, ASTHMA AND IMMUNOLOGY (IJAAI), vol. 18, no. 6, pp. 649–654, 2019, [Online]. Available: https://sid.ir/paper/761624/en

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