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Information Journal Paper

Title

Infectious Complications in Patients with Common Variable Immunodeficiency (CVID) in Iran

Pages

  40-50

Abstract

 Background/objectives: CVID is a common primary immunodeficiency (CVID) is a common primary immunodeficiency disease that can be defined as a failure in B cell differentiation and impaired immunoglobulin production. Subsequently, the CVID patients are remarkably susceptible to recurrent and multiple infections with bacterial, viral or fungal agents. In the present study, we aimed to provide an update report on different infectious complications in the patients with CVID in Iran. Methods: Demographic, clinical, and immunologic data as well as a history of infections with the related microbial pathogens were obtained from records of the patients diagnosed with CVID, and were followed up at Children’ s Medical Center. Based on the presence of meningitis, osteomyelitis, and sepsis; 2 groups of severe infections and non-severe infections were selected for further investigations. Results: Among 301 CVID patients enrolled, 15 (5%) had severe and 286 (95%) had non-severe infections. Respiratory followed by gastrointestinal tract problems (83. 1 and 71. 4%, respectively) were the most common involved organs. Out of the infectious complications, lower and upper respiratory tract infection followed by mucocutaneous and gastrointestinal tract, were the most frequent ones (76. 1, 64. 8, 21. 6, and 19. 6%, respectively). Also, Candida followed by Giardia lamblia were the most common detected pathogens in those with opportunistic infections and infectious diarrhea, respectively. Conclusions: Recurrent infections of various parts of the body are the most prevalent manifestation among the patients with CVID, which play an important role in the morbidity and even mortality in those with prolonged and untreated infections. Recurrent infections initiating early in childhood should be paid more attention, and trigger further immunological work up for a possible underlying immunodeficiency, especially in those families with consanguineous marriage and/or a positive family history of primary immunodeficiency.

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    APA: Copy

    shirmast, Paniz, Mehrizi, Reza, & Fekrvand, Saba. (2020). Infectious Complications in Patients with Common Variable Immunodeficiency (CVID) in Iran. IMMUNOLOGY AND GENETICS JOURNA, 3(1), 40-50. SID. https://sid.ir/paper/761746/en

    Vancouver: Copy

    shirmast Paniz, Mehrizi Reza, Fekrvand Saba. Infectious Complications in Patients with Common Variable Immunodeficiency (CVID) in Iran. IMMUNOLOGY AND GENETICS JOURNA[Internet]. 2020;3(1):40-50. Available from: https://sid.ir/paper/761746/en

    IEEE: Copy

    Paniz shirmast, Reza Mehrizi, and Saba Fekrvand, “Infectious Complications in Patients with Common Variable Immunodeficiency (CVID) in Iran,” IMMUNOLOGY AND GENETICS JOURNA, vol. 3, no. 1, pp. 40–50, 2020, [Online]. Available: https://sid.ir/paper/761746/en

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