Innovative evaluation of local injective gel of curcumin on the orthodontic tooth movement in rats

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ASEFI SOHRAB; SEIFI MASSOUD; Hatami Fard Ghazal; LOTFI ALI

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Journal: Dental Research Journal Year:2018 | Volume:15 | Issue:1 Page(s): 40-49

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Title

Innovative evaluation of local injective gel of curcumin on the orthodontic tooth movement in rats

Author(s)

ASEFI SOHRAB | SEIFI MASSOUD | Hatami Fard Ghazal | LOTFI ALI | Issue Writer Certificate

Keywords

Bone resorption

curcumin

rat

root resorption

tooth movement

Abstract

Background: curcumin is the most active compound in turmeric. It can suppress the nuclear factor kappa‑ light‑ chain‑ enhancer of activated B cells pathway and prevent the osteoclastogenesis procedure. This study aimed to be the first to evaluate the effect of curcumin on the rate of orthodontic tooth movement (OTM). Materials and Methods: Forty rats were used as follows in each group: (1) negative control: Did not receive any appliance or injection; (2) positive control: received 0. 03 cc normal saline and appliance; (3) gelatin plus curcumin (G): Received 0. 03 cc hydrogel and appliance; and (4) chitosan plus curcumin (Ch): Received 0. 03 cc hydrogel and appliance. They were anesthetized and closed nickel‑ titanium coil springs were installed between the first molars and central incisors unilaterally as the orthodontic appliance. After 21 days, the rats were decapitated, and the distance between the first and second molars was measured by a leaf gauge. Howship’ s lacunae, blood vessels, osteoclast‑ like cells, and root resorption lacunae were evaluated in the histological analysis. Data were analyzed by one‑ way ANOVA, Tukey’ s test, and t‑ test (P < 0. 05 consider significant). Results: No significant difference was found in OTM between groups delivered orthodontic forces. curcumin inhibited root and Bone resorption, osteoclastic recruitment, and angiogenesis significantly. Conclusion: curcumin had no significant inhibitory effect on OTM. While it had a significant role on decreasing bone or root resorption (P > 0. 05).

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APA: Copy

ASEFI, SOHRAB, SEIFI, MASSOUD, Hatami Fard, Ghazal, & LOTFI, ALI. (2018). Innovative evaluation of local injective gel of curcumin on the orthodontic tooth movement in rats. DENTAL RESEARCH JOURNAL, 15(1), 40-49. SID. https://sid.ir/paper/761976/en

Vancouver: Copy

ASEFI SOHRAB, SEIFI MASSOUD, Hatami Fard Ghazal, LOTFI ALI. Innovative evaluation of local injective gel of curcumin on the orthodontic tooth movement in rats. DENTAL RESEARCH JOURNAL[Internet]. 2018;15(1):40-49. Available from: https://sid.ir/paper/761976/en

IEEE: Copy

SOHRAB ASEFI, MASSOUD SEIFI, Ghazal Hatami Fard, and ALI LOTFI, “Innovative evaluation of local injective gel of curcumin on the orthodontic tooth movement in rats,” DENTAL RESEARCH JOURNAL, vol. 15, no. 1, pp. 40–49, 2018, [Online]. Available: https://sid.ir/paper/761976/en

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