DETERMINATION OF EFFECT OF LOW DOSE VS MODERATE DOSE CLOFIBRATE ON DECREASING SERUM BILIRUBIN IN HEALTHY TERM NEONATES

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MOSLEHI M.A.; PISHVA N.

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Journal: Iranian Journal of Pediatrics Year:2007 | Volume:17 | Issue:2 Page(s): 108-112

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Title

DETERMINATION OF EFFECT OF LOW DOSE VS MODERATE DOSE CLOFIBRATE ON DECREASING SERUM BILIRUBIN IN HEALTHY TERM NEONATES

Author(s)

MOSLEHI M.A. | PISHVA N. | Issue Writer Certificate

Keywords

CLOFIBRATEQ3

NEONATAL HYPERBILIRUBINEMIAQ3

PHOTOTHERAPYQ3

JAUNDICEQ2

Abstract

Objective: This study was performed to determine the effect of low doses (25 mg/Kg) vs. moderate doses (50 mg/Kg) of CLOFIBRATE in treatment of non-hemolytic hyperbilirubinemia in healthy term neonates.Material & Methods: A clinical randomized controlled trial was performed in three groups of healthy term neonates. One group was treated with a single low dose of CLOFIBRATE (25 mg/Kg) while another group received a single moderate dose (50mg/kg) both orally plus PHOTOTHERAPY; the results were compared with those of a control group that received only PHOTOTHERAPY.Findings: The mean total serum bilirubin (TSB) levels of 12th and 24th hours were significantly lower in the two CLOFIBRATE-treated groups as compared with the control group (P=0.002 and P=0.003, respectively). There was no statistically significant difference between the mean of TSB levels in the two CLOFIBRATE-treated groups. Treatment with CLOFIBRATE also resulted in a shorter duration of JAUNDICE and a decreased use of PHOTOTHERAPY (P=0.01). No side effects were observed.Conclusion: The present study demonstrated that there was no significant difference between a low (25mg/Kg) and moderate (50mg/Kg) doses of CLOFIBRATE in reducing TSB levels and also decreased need of PHOTOTHERAPY in healthy breastfed term newborns with marked hyperbilirubinemia (TSB>16 mg/dL).

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APA: Copy

MOSLEHI, M.A., & PISHVA, N.. (2007). DETERMINATION OF EFFECT OF LOW DOSE VS MODERATE DOSE CLOFIBRATE ON DECREASING SERUM BILIRUBIN IN HEALTHY TERM NEONATES. IRANIAN JOURNAL OF PEDIATRICS, 17(2), 108-112. SID. https://sid.ir/paper/76217/en

Vancouver: Copy

MOSLEHI M.A., PISHVA N.. DETERMINATION OF EFFECT OF LOW DOSE VS MODERATE DOSE CLOFIBRATE ON DECREASING SERUM BILIRUBIN IN HEALTHY TERM NEONATES. IRANIAN JOURNAL OF PEDIATRICS[Internet]. 2007;17(2):108-112. Available from: https://sid.ir/paper/76217/en

IEEE: Copy

M.A. MOSLEHI, and N. PISHVA, “DETERMINATION OF EFFECT OF LOW DOSE VS MODERATE DOSE CLOFIBRATE ON DECREASING SERUM BILIRUBIN IN HEALTHY TERM NEONATES,” IRANIAN JOURNAL OF PEDIATRICS, vol. 17, no. 2, pp. 108–112, 2007, [Online]. Available: https://sid.ir/paper/76217/en

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