Interferon-Gamma-Inducible Guanosine Triphosphate Cyclohydrolase 1 (GTP-CH1) Pathway Is Associated with Frailty in Egyptian Elderly

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Mohamad Magda; Ebeid Somaia; Shawky Khater Mohamed; Alsadany Mohamad

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Paper Information

Journal: REPORTS OF BIOCHEMISTRY AND MOLECULAR BIOLOGY Year:2018 | Volume:7 | Issue:1 Page(s): 52-58

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Title

Interferon-Gamma-Inducible Guanosine Triphosphate Cyclohydrolase 1 (GTP-CH1) Pathway Is Associated with Frailty in Egyptian Elderly

Author(s)

Mohamad Magda | Ebeid Somaia | Shawky Khater Mohamed | Alsadany Mohamad | Issue Writer Certificate

Keywords

Frailty

GTP-CH1 pathway

INF-γ.

Abstract

Background: Chronic low-grade inflammation may be a cardinal pathophysiologic feature in the pathogenesis of Frailty. Interferon-gamma (INF-γ.) is an understudied proinflammatory cytokine in Frailty that induces many inflammatory pathways including the guanosine triphosphate cyclohydrolase 1 (GTP-CH1) pathway. Our aim was to evaluate the GTP-CH1 pathway in Egyptian frail elderly subjects. Methods: INF-γ., neopterin, and nitric oxide (NO) levels were measured in 80 participants. Results: Both pre-frail and frail subjects had significantly higher levels of INF-γ., neopterin and lower levels of NO than the control group. These biomarkers were associated with the risk of Frailty with significant odds ratio. Conclusions: Elevated INF-γ.levels in frail subjects may activate the GTP-CH1 pathway. Elevated neopterin and reduced NO levels correlated with an active GTP-CH1 pathway. The risk of Frailty increased with elevated INF-γ.and neopterin and decreased with elevated NO levels.

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APA: Copy

Mohamad, Magda, Ebeid, Somaia, Shawky Khater, Mohamed, & Alsadany, Mohamad. (2018). Interferon-Gamma-Inducible Guanosine Triphosphate Cyclohydrolase 1 (GTP-CH1) Pathway Is Associated with Frailty in Egyptian Elderly. REPORTS OF BIOCHEMISTRY AND MOLECULAR BIOLOGY, 7(1), 52-58. SID. https://sid.ir/paper/762213/en

Vancouver: Copy

Mohamad Magda, Ebeid Somaia, Shawky Khater Mohamed, Alsadany Mohamad. Interferon-Gamma-Inducible Guanosine Triphosphate Cyclohydrolase 1 (GTP-CH1) Pathway Is Associated with Frailty in Egyptian Elderly. REPORTS OF BIOCHEMISTRY AND MOLECULAR BIOLOGY[Internet]. 2018;7(1):52-58. Available from: https://sid.ir/paper/762213/en

IEEE: Copy

Magda Mohamad, Somaia Ebeid, Mohamed Shawky Khater, and Mohamad Alsadany, “Interferon-Gamma-Inducible Guanosine Triphosphate Cyclohydrolase 1 (GTP-CH1) Pathway Is Associated with Frailty in Egyptian Elderly,” REPORTS OF BIOCHEMISTRY AND MOLECULAR BIOLOGY, vol. 7, no. 1, pp. 52–58, 2018, [Online]. Available: https://sid.ir/paper/762213/en

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