Cytomegalovirus End Organ Disease in Iranian HIV-1 Infected Patients with CD4+ Cell Counts Less Than 100 Cells/mm3

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JABBARI MOHAMMADREZA; SOLEIMANJAHI HOORIEH; HAJIABDOLBAGHI MAHBOUBEH; Sarraf Shirazi Mohammad; SHATIZADEH MALEKSHAHI SOMAYEH

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Journal: Iranian Red Crescent Medical Journal Year:2019 | Volume:21 | Issue:11 Page(s): 0-0

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Title

Cytomegalovirus End Organ Disease in Iranian HIV-1 Infected Patients with CD4+ Cell Counts Less Than 100 Cells/mm3

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Keywords

AIDS-related Opportunistic Infections

CD4+ Lymphocyte Count

Epidemiology

Abstract

Background: Cytomegalovirus End-Organ Disease (CMV-EOD) is a seriously debilitating illness in patients with advanced HIV-1 infection, typically occurring with CD4+ cell counts of < 100 cells/mm3. Objectives: This study aimed to evaluate the prevalence of CMV-EOD in adult patients with advanced HIV-1 infection (CD4+ count < 100 cells/mm3). Methods: Using a convenience sampling method, a cross-sectional study was conducted on 82 patients with advanced HIV-1 infection in Iran between April 2016 and April 2018. We collected baseline characteristics (age, sex, route of HIV-1 transmission, Hepatitis C Virus (HCV) infection, Hepatitis B Virus (HBV) infection, CMV IgG, and treatment status for HIV-1 infection) and CD4 counts. The entire patients underwent clinical examinations for the diagnosis of CMV-EOD by experienced clinicians. Statistical analysis was used to measure the differences between categorical variables and the outcome of CMV-EOD diagnosis. Results: Fourteen (17. 07%) out of 82 HIV-1-infected patients were diagnosed with opportunistic infection due to CMV. Among 14 patients with CMV-EOD, retinitis occurred in the majority of patients (64. 28%), followed by colitis (21. 42%) and encephalitis (14. 28%). No significant correlation was found between the outcome of CMV-EOD and HBV infection (P = 1. 00), HCV infection (P = 0. 55), and treatment status for HIV-1 infection (P = 0. 53). We detected CMV-EOD more frequently among injecting drug users and patients with positive CMV-IgG (P = 0. 12 and P = 0. 41, respectively). The ophthalmic examination had clinical usefulness for HIV-1 positive patients with CD4 counts of < 100/mm3. Conclusions: It is assumed that the CD4+ cell count is not the sole predictor of the risk of developing CMV-EOD. Further large-scale studies are required for a better understanding of risk factors involved in the occurrence of CMV-EOD in HIV-1 positive patients.

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APA: Copy

JABBARI, MOHAMMADREZA, SOLEIMANJAHI, HOORIEH, HAJIABDOLBAGHI, MAHBOUBEH, Sarraf Shirazi, Mohammad, & SHATIZADEH MALEKSHAHI, SOMAYEH. (2019). Cytomegalovirus End Organ Disease in Iranian HIV-1 Infected Patients with CD4+ Cell Counts Less Than 100 Cells/mm3. IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ), 21(11), 0-0. SID. https://sid.ir/paper/762398/en

Vancouver: Copy

JABBARI MOHAMMADREZA, SOLEIMANJAHI HOORIEH, HAJIABDOLBAGHI MAHBOUBEH, Sarraf Shirazi Mohammad, SHATIZADEH MALEKSHAHI SOMAYEH. Cytomegalovirus End Organ Disease in Iranian HIV-1 Infected Patients with CD4+ Cell Counts Less Than 100 Cells/mm3. IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ)[Internet]. 2019;21(11):0-0. Available from: https://sid.ir/paper/762398/en

IEEE: Copy

MOHAMMADREZA JABBARI, HOORIEH SOLEIMANJAHI, MAHBOUBEH HAJIABDOLBAGHI, Mohammad Sarraf Shirazi, and SOMAYEH SHATIZADEH MALEKSHAHI, “Cytomegalovirus End Organ Disease in Iranian HIV-1 Infected Patients with CD4+ Cell Counts Less Than 100 Cells/mm3,” IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ), vol. 21, no. 11, pp. 0–0, 2019, [Online]. Available: https://sid.ir/paper/762398/en

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