مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

video

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

sound

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Version

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

View:

113
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Download:

69
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Cites:

Information Journal Paper

Title

Comparison of Pregnancy Rate in Patients With Polycystic Ovary Syndrome Treated With Clomiphene Alone and in Combination With N-acetyl Cysteine: A Randomized Clinical Trial

Pages

  185-189

Abstract

 Objectives: Polycystic ovary syndrome (PCOS) is one of the frequent endocrine disorders among young females, which can cause Infertility. Recently, evidence has shown the beneficial impacts of N-acetyl cysteine (NAC) use along with Clomiphene citrate on the treatment of Infertility caused by PCOS. Regarding this, the present study aimed to compare the pregnancy rate between the PCOS patients treated with clomiphene and those received clomiphene along with NAC. Materials and Methods: This blinded randomized controlled clinical trial was performed on 66 patients with PCOS who presented with Infertility at Milad Infertility Center in Mashhad, Iran, in 2015. The patients were divided into two groups of intervention and control using a random number table. In the intervention group, 100 mg of clomiphene (i. e. two pills) along with 1200 mg of NAC (i. e. two 600 mg pills) were given to the participants from the third day of the menstrual cycle for five days. In the control group, 100 mg of clomiphene was administered from the third day of the cycle for 5 days. The patients’ response to medications as well as the number and size of follicles were assessed using the vaginal ultrasound. Results: The 2 study groups had no significant difference regarding age, duration of Infertility, body mass index, history of Infertility treatment, and endometrial thickness on the third day of the menstrual cycle. The mean endometrial thickness was 7. 47 ± 1. 6 (NAC/clomiphene) and 7. 58 ± 2. 1 mm (clomiphene) on the 12th day of the menstrual cycle (P = 0. 810). Furthermore, the mean sizes of the follicles were 13. 6 ± 4. 2 (clomiphene) and 15. 9 ± 5. 1 mm (NAC/clomiphene) (P = 0. 301). The mean numbers of follicles were 1. 56 ± 0. 9 (clomiphene) and 1. 8 ± 0. 9 (NAC/clomiphene) (P = 0. 069). In total, 7 (21. 2%) and 5 (15. 1%) patients in the intervention and control groups had a positive beta-hCG result, respectively (P = 0. 260). Conclusions: As the findings of this study revealed, the addition of NAC to clomiphene treatment was not associated with an increased chance of pregnancy in patients with PCOS-related Infertility.

Cites

  • No record.

    • References

  • No record.

    • Cite

    APA: Copy

    GHOMIAN, NAYEREH, KHADEM, NAYEREH, MOEINDARBARI, SOMAYEH, & Abdolrazagh, Aghdas. (2019). Comparison of Pregnancy Rate in Patients With Polycystic Ovary Syndrome Treated With Clomiphene Alone and in Combination With N-acetyl Cysteine: A Randomized Clinical Trial. INTERNATIONAL JOURNAL OF WOMEN’S HEALTH AND REPRODUCTION SCIENCES, 7(2), 185-189. SID. https://sid.ir/paper/762526/en

    Vancouver: Copy

    GHOMIAN NAYEREH, KHADEM NAYEREH, MOEINDARBARI SOMAYEH, Abdolrazagh Aghdas. Comparison of Pregnancy Rate in Patients With Polycystic Ovary Syndrome Treated With Clomiphene Alone and in Combination With N-acetyl Cysteine: A Randomized Clinical Trial. INTERNATIONAL JOURNAL OF WOMEN’S HEALTH AND REPRODUCTION SCIENCES[Internet]. 2019;7(2):185-189. Available from: https://sid.ir/paper/762526/en

    IEEE: Copy

    NAYEREH GHOMIAN, NAYEREH KHADEM, SOMAYEH MOEINDARBARI, and Aghdas Abdolrazagh, “Comparison of Pregnancy Rate in Patients With Polycystic Ovary Syndrome Treated With Clomiphene Alone and in Combination With N-acetyl Cysteine: A Randomized Clinical Trial,” INTERNATIONAL JOURNAL OF WOMEN’S HEALTH AND REPRODUCTION SCIENCES, vol. 7, no. 2, pp. 185–189, 2019, [Online]. Available: https://sid.ir/paper/762526/en

    Related Journal Papers

  • No record.

    • Related Seminar Papers

  • No record.

    • Related Plans

  • No record.

    • Recommended Workshops






    Move to top
    telegram sharing button
    whatsapp sharing button
    linkedin sharing button
    twitter sharing button
    email sharing button
    email sharing button
    email sharing button
    sharethis sharing button