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Information Journal Paper

Title

Evaluation of the Antileishmanial Properties of Ixora brachiata Roxb on Leishmania major and Leishmania infantum by Colorimetric MTT Assay

Pages

  126-129

Abstract

 Background: Leishmaniasis is a major global health problem which affects millions of people, especially in the developing countries. The incidence of leishmaniasis has increased and there is no vaccination for Leishmania infections and standard drugs for treatment of the disease have many side effects; therefore, it is necessary to find new effective alternatives. Objectives: The purpose of this study was to evaluate the in vitro Antileishmanial activity of Ixora brachiata root extract against Leishmania major and Leishmania infantum Promastigotes. Materials and Methods: Different doses of the selected plant extract was tested against L. major and L. infantum Promastigotes using Colorimetric MTT [3-(4, 5-methylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide] assay. Glucantime was used as the positive control. Results: Anti-parasitic activity was revealed for I. brachiata root on L. major and L. infantum with 50% inhibitory concentration (IC50) values of 0. 91 and 2. 63 μ g/mL, respectively compared to the standard drugs, glucantime, which had an IC50 value of 40. 2 μ g/mL for L. major and 18. 5 μ g/mL for L. infantum after 72 hours.

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    Cite

    APA: Copy

    Eskandari, Kaveh, KHADEMVATAN, SHAHRAM, SADEGHI NEJAD, BATOOL, YUSEF NAANAIE, SEDIGHEH, & Kohansal, Kobra. (2019). Evaluation of the Antileishmanial Properties of Ixora brachiata Roxb on Leishmania major and Leishmania infantum by Colorimetric MTT Assay. INTERNATIONAL JOURNAL OF ENTERIC PATHOGEN, 7(4), 126-129. SID. https://sid.ir/paper/762580/en

    Vancouver: Copy

    Eskandari Kaveh, KHADEMVATAN SHAHRAM, SADEGHI NEJAD BATOOL, YUSEF NAANAIE SEDIGHEH, Kohansal Kobra. Evaluation of the Antileishmanial Properties of Ixora brachiata Roxb on Leishmania major and Leishmania infantum by Colorimetric MTT Assay. INTERNATIONAL JOURNAL OF ENTERIC PATHOGEN[Internet]. 2019;7(4):126-129. Available from: https://sid.ir/paper/762580/en

    IEEE: Copy

    Kaveh Eskandari, SHAHRAM KHADEMVATAN, BATOOL SADEGHI NEJAD, SEDIGHEH YUSEF NAANAIE, and Kobra Kohansal, “Evaluation of the Antileishmanial Properties of Ixora brachiata Roxb on Leishmania major and Leishmania infantum by Colorimetric MTT Assay,” INTERNATIONAL JOURNAL OF ENTERIC PATHOGEN, vol. 7, no. 4, pp. 126–129, 2019, [Online]. Available: https://sid.ir/paper/762580/en

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