COVID-19 Patients Suffer From DHEA-S Sufficiency

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VAEZ MAHDAVI MOHAMMAD REZA; KABOUDANIAN ARDESTANI SUSSAN; REZAEI AREZOU; MOHAMMADI SAEED; RAJABNIA CHENARY MARYAM; Gharegozlou Behnaz; NAGHIZADEH MOHAMMAD MEHDI; GHAZANFARI TOOBA

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Journal: ImmunoRegulation Year:2021 | Volume:3 | Issue:2 Page(s): 135-144

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Title

COVID-19 Patients Suffer From DHEA-S Sufficiency

Author(s)

Keywords

COVID-19

DHEA-S

DHEA-S/cortisol

DHEA supplementation

Iran

Abstract

Background: The nervous, endocrine, and immune systems contribute to the response and dynamic adaption to various stresses. Activation of the hypothalamic-pituitary-adrenal axis has been demonstrated in various active critical illnesses. Novel Coronavirus Disease 2019 (COVID-19), caused by Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2), is a disease with age and gender disparities. Materials and Methods: In this study, a total of 125 consecutive inpatients with COVID-19 admitted to Imam Khomeini Hospital Complex from February 12, 2020, to April 4, 2020, were enrolled. The severity of patients was classified into three subgroups based on the types of oxygen therapies. Dehydroepiandrosterone Sulfate (DHEA-S) and cortisol levels were measured in serum of inpatients with Siemens kit. Results: While the increase in cortisol level was not significant in COVID-19 patients, the DHEA-S level and DHEA-S/cortisol ratio significantly decreased in the patients with the increase in severity of the disease. Conclusion: We proposed that the supplementation of DHEA, the precursor of both androgens and steroids, may ameliorate adverse outcomes of COVID-19 disease and improve COVID-19 patients’ ability to survive.

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APA: Copy

VAEZ MAHDAVI, MOHAMMAD REZA, KABOUDANIAN ARDESTANI, SUSSAN, REZAEI, AREZOU, MOHAMMADI, SAEED, RAJABNIA CHENARY, MARYAM, Gharegozlou, Behnaz, NAGHIZADEH, MOHAMMAD MEHDI, & GHAZANFARI, TOOBA. (2021). COVID-19 Patients Suffer From DHEA-S Sufficiency. IMMUNOREGULATION, 3(2), 135-144. SID. https://sid.ir/paper/763717/en

Vancouver: Copy

VAEZ MAHDAVI MOHAMMAD REZA, KABOUDANIAN ARDESTANI SUSSAN, REZAEI AREZOU, MOHAMMADI SAEED, RAJABNIA CHENARY MARYAM, Gharegozlou Behnaz, NAGHIZADEH MOHAMMAD MEHDI, GHAZANFARI TOOBA. COVID-19 Patients Suffer From DHEA-S Sufficiency. IMMUNOREGULATION[Internet]. 2021;3(2):135-144. Available from: https://sid.ir/paper/763717/en

IEEE: Copy

MOHAMMAD REZA VAEZ MAHDAVI, SUSSAN KABOUDANIAN ARDESTANI, AREZOU REZAEI, SAEED MOHAMMADI, MARYAM RAJABNIA CHENARY, Behnaz Gharegozlou, MOHAMMAD MEHDI NAGHIZADEH, and TOOBA GHAZANFARI, “COVID-19 Patients Suffer From DHEA-S Sufficiency,” IMMUNOREGULATION, vol. 3, no. 2, pp. 135–144, 2021, [Online]. Available: https://sid.ir/paper/763717/en

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