Interleukin-6 as a Potential Predictor of COVID-19 Disease Severity in Hospitalized Patients and its Association With Clinical Laboratory Routine Tests

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

ROSTAMIAN ABDOLRAHMAN; GHAZANFARI TOOBA; ARABKHERADMAND JALIL; EDALATIFARD MARYAM; GHAFFARPOUR SARA; SALEHI MOHAMMAD REZA; Raeeskarami Seyed Reza; Mahmoodi Aliabadi Maedeh; RAJABNIA CHENARY MARYAM; MIRSHARIF ENSIE SADAT; JAMALI DAVOUD; Sattarian Mohammad Reza; NAJAFIZADEH SEYED REZA; Hosseinieselki Sari Sajjad; Jafarpour Samira; Nezhadseifi Elham; Movasseghi Shafieh; Baharvand Elahe; Beiranvand Saba; Roomi Azin; NAGHIZADEH MOHAMMAD MEHDI

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: ImmunoRegulation Year:2020 | Volume:3 | Issue:1 Page(s): 29-36

Download Full-Text

View:

410

Download:

334

Cites:

Information Journal Paper

Title

Interleukin-6 as a Potential Predictor of COVID-19 Disease Severity in Hospitalized Patients and its Association With Clinical Laboratory Routine Tests

Author(s)

Keywords

Coronavirus Disease 2019 (COVID-19)

Severe Acute Respiratory Syndrome Coronavirus 2 (SARSCov-2)

Interleukin-6

Biochemical routine tests

Mechanical ventilation

Abstract

Background: Researchers have already reported a high level of interleukin (IL)-6 in patients affected by Coronavirus Disease 2019 (COVID-19). In this study, we investigated the surge of IL-6 level and its association with the clinical and paraclinical markers in these patients. Materials and Methods: The study sample comprised 205 confirmed hospitalized patients with Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) and 70 healthy volunteer individuals. Routine laboratory examinations, including hematology, biochemistry, and hormone analysis, as well as IL-6 level measurement, were conducted. The patients grouped into 5 based on their IL-6 levels. Then, they were compared with regard to their need for mechanical ventilator and clinical laboratory routine tests. Results: IL-6 levels were significantly higher in hospitalized patients compared with healthy individuals (P<0. 001). The IL-6 level was approximately 10-fold of the normal range in 22. 9% of the patients. Also, more than 56. 1% of them signify IL-6 over 3-fold of the normal range. IL-6 raised level was crucially associated with the need for a mechanical ventilator. The values of highdensity lipoproteins, low-density lipoproteins, very low-density lipoproteins, red blood cells, platelets, lymphocytes, monocytes, and eosinophils showed an indirect linear trend and the levels of low-density lipoproteins, serum glutamic oxaloacetic transaminase, serum glutamic pyruvic transaminase, creatine phosphokinase, ferritin, C-reactive protein, white blood cells, and neutrophil demonstrated a direct linear trend with elevating rate of IL-6. Conclusion: Elevated levels of IL-6 probably threaten the vital factors and have a crucial role in immune-mediated acute lung injury in CIOVID-19 patients. Some routine clinical laboratory tests are a proper alternative for determining the amount of IL-6 in these patients.

Cites

References

Cite

APA: Copy

ROSTAMIAN, ABDOLRAHMAN, GHAZANFARI, TOOBA, ARABKHERADMAND, JALIL, EDALATIFARD, MARYAM, GHAFFARPOUR, SARA, SALEHI, MOHAMMAD REZA, Raeeskarami, Seyed Reza, Mahmoodi Aliabadi, Maedeh, RAJABNIA CHENARY, MARYAM, MIRSHARIF, ENSIE SADAT, JAMALI, DAVOUD, Sattarian, Mohammad Reza, NAJAFIZADEH, SEYED REZA, Hosseinieselki Sari, Sajjad, Jafarpour, Samira, Nezhadseifi, Elham, Movasseghi, Shafieh, Baharvand, Elahe, Roomi, Azin, NAGHIZADEH, MOHAMMAD MEHDI, & Beiranvand, Saba. (2020). Interleukin-6 as a Potential Predictor of COVID-19 Disease Severity in Hospitalized Patients and its Association With Clinical Laboratory Routine Tests. IMMUNOREGULATION, 3(1), 29-36. SID. https://sid.ir/paper/766533/en

Vancouver: Copy

ROSTAMIAN ABDOLRAHMAN, GHAZANFARI TOOBA, ARABKHERADMAND JALIL, EDALATIFARD MARYAM, GHAFFARPOUR SARA, SALEHI MOHAMMAD REZA, Raeeskarami Seyed Reza, Mahmoodi Aliabadi Maedeh, RAJABNIA CHENARY MARYAM, MIRSHARIF ENSIE SADAT, JAMALI DAVOUD, Sattarian Mohammad Reza, NAJAFIZADEH SEYED REZA, Hosseinieselki Sari Sajjad, Jafarpour Samira, Nezhadseifi Elham, Movasseghi Shafieh, Baharvand Elahe, Roomi Azin, NAGHIZADEH MOHAMMAD MEHDI, Beiranvand Saba. Interleukin-6 as a Potential Predictor of COVID-19 Disease Severity in Hospitalized Patients and its Association With Clinical Laboratory Routine Tests. IMMUNOREGULATION[Internet]. 2020;3(1):29-36. Available from: https://sid.ir/paper/766533/en

IEEE: Copy

ABDOLRAHMAN ROSTAMIAN, TOOBA GHAZANFARI, JALIL ARABKHERADMAND, MARYAM EDALATIFARD, SARA GHAFFARPOUR, MOHAMMAD REZA SALEHI, Seyed Reza Raeeskarami, Maedeh Mahmoodi Aliabadi, MARYAM RAJABNIA CHENARY, ENSIE SADAT MIRSHARIF, DAVOUD JAMALI, Mohammad Reza Sattarian, SEYED REZA NAJAFIZADEH, Sajjad Hosseinieselki Sari, Samira Jafarpour, Elham Nezhadseifi, Shafieh Movasseghi, Elahe Baharvand, Azin Roomi, MOHAMMAD MEHDI NAGHIZADEH, and Saba Beiranvand, “Interleukin-6 as a Potential Predictor of COVID-19 Disease Severity in Hospitalized Patients and its Association With Clinical Laboratory Routine Tests,” IMMUNOREGULATION, vol. 3, no. 1, pp. 29–36, 2020, [Online]. Available: https://sid.ir/paper/766533/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops