MECHANISM OF CEA RELEASE FROM THE MALIGNANT CELLS OF COLORECTAL CARCINOMA

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EBADI PADIDEH; NAGHIB ALHOSSEINI F.A.D.

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Journal: Scientific Journal of Kurdistan University of Medical Sciences Year:2007 | Volume:12 | Issue:2 (SERIAL NUMBER 44) Page(s): 61-76

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Information Journal Paper

Title

MECHANISM OF CEA RELEASE FROM THE MALIGNANT CELLS OF COLORECTAL CARCINOMA

Author(s)

EBADI PADIDEH | NAGHIB ALHOSSEINI F.A.D. | Issue Writer Certificate

Keywords

CARCINOEMBRYONIC ANTIGEN (CEA)Q3

GPI-SPECIFIC PI-PLD (GPI-PLD)Q3

GLYCOPHOSPHATIDYL INOSITOL (GPI) ANCHORQ3

Abstract

Background and Aim: Carcinoembryonic antigen (CEA) is one of the most frequently used tumor markers which is over-expressed in a variety of human cancers with epithelial origin such as colorectal, gastric, pancreatic, lung and breast cancers. The precise mechanism by which CEA is released from the cell surface into serum in cancer patients has not been clarified so far. CEA is attached to the plasma membrane by a glycophosphatidyl inositol (GPI) anchor. There have been some evidences indicating a possible role for involvement of an enzyme in CEA release from the cell surface. The GPI-anchor is a substrate for specific phospholipases. According to this information, we investigated the possible role of GPI specific PI-PLD (GPI-PLD) in hydrolysis and CEA release.Materials and Methods: We have, therefore, used reverse transcription-polymerase chain reaction (RT-PCR) to verify GPI-PLD expression in some cell lines of colorectal adenocarcinoma. The amount of CEA released from a high CEA producing cell line in the presence or absence of specific activators / inhibitors of this enzyme were measured.Results: Using RT-PCR, expression of GPI-PLD gene in these cell lines can be demonstrated.The amount of CEA released from high producing cell lines are increased or decreased in the presence or absence of specific activators / inhibitors.Conclusion: According to this study there are evidences implicating the role of GPI-PLD enzyme in releasing CEA from the surface of the cells of colorectal carcinoma.

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APA: Copy

EBADI, PADIDEH, & NAGHIB ALHOSSEINI, F.A.D.. (2007). MECHANISM OF CEA RELEASE FROM THE MALIGNANT CELLS OF COLORECTAL CARCINOMA. SCIENTIFIC JOURNAL OF KURDISTAN UNIVERSITY OF MEDICAL SCIENCES, 12(2 (SERIAL NUMBER 44)), 61-76. SID. https://sid.ir/paper/76374/en

Vancouver: Copy

EBADI PADIDEH, NAGHIB ALHOSSEINI F.A.D.. MECHANISM OF CEA RELEASE FROM THE MALIGNANT CELLS OF COLORECTAL CARCINOMA. SCIENTIFIC JOURNAL OF KURDISTAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2007;12(2 (SERIAL NUMBER 44)):61-76. Available from: https://sid.ir/paper/76374/en

IEEE: Copy

PADIDEH EBADI, and F.A.D. NAGHIB ALHOSSEINI, “MECHANISM OF CEA RELEASE FROM THE MALIGNANT CELLS OF COLORECTAL CARCINOMA,” SCIENTIFIC JOURNAL OF KURDISTAN UNIVERSITY OF MEDICAL SCIENCES, vol. 12, no. 2 (SERIAL NUMBER 44), pp. 61–76, 2007, [Online]. Available: https://sid.ir/paper/76374/en

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