THE PROTECTIVE EFFECTS OF TANACETUM PARTHENIUM EXTRACT ON CCL4-INDUCED MYOCARDIUM INJURY IN RATS

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MAZANI M.; MAHMOODZADEH Y.; REZAGHOLIZADEH L.

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Journal: SCIENTIFIC JOURNAL OF KURDISTAN UNIVERSITY OF MEDICAL SCIENCES Year:2018 | Volume:23 | Issue:2 (94) Page(s): 70-80

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Title

THE PROTECTIVE EFFECTS OF TANACETUM PARTHENIUM EXTRACT ON CCL4-INDUCED MYOCARDIUM INJURY IN RATS

Author(s)

MAZANI M. | MAHMOODZADEH Y. | REZAGHOLIZADEH L. | Issue Writer Certificate

Keywords

TANACETUM PARTHENIUMQ1

CARBON TETRACHLORIDEQ2

MYOCARDIUMQ1

LIPID PEROXIDATIONQ2

ANTIOXIDANTQ2

Abstract

Background and Aim: The aim of this study was to investigate the protective effects of TANACETUM PARTHENIUMextract (TPE) on LIPID PEROXIDATION and acute heart injury induced by CARBON TETRACHLORIDE (CCl4) in rats.Materials and Methods: In an experimental study, 30 male Wistar rats were divided into 5 groups (n=6). Two of the groups were normal and damage control groups, other 3 groups were damage groups treated with 40, 80 and 120 mg / kg of TPE for 14 days before being damaged by CCl4. At the end of the study we measured the activity of creatine kinase (CKMB) isoenzyme and lactate dehydrogenase (LDH), total cholesterol (TC), HDL-C and LDL-C in serum, as well as the activity of superoxide dismutase (SOD), glutathione peroxidase (GPX), and arylesterase (ARE) and malondialdehyde (MDA) concentration, as LIPID PEROXIDATION index, in myocardial homogenates.Results: The results of this study showed that treatment with CARBON TETRACHLORIDE significantly increased the levels of CK-MB, LDH, TC, LDL-C and MDA and decreased ARE, HDL-C, SOD and GPX (P<0.001) in a dose dependent manner.Conclusion: The present study demonstrated that TPE can be considered as a substance with various potential effects such as ANTIOXIDANT activity and cardioprotective effects.

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APA: Copy

MAZANI, M., MAHMOODZADEH, Y., & REZAGHOLIZADEH, L.. (2018). THE PROTECTIVE EFFECTS OF TANACETUM PARTHENIUM EXTRACT ON CCL₄-INDUCED MYOCARDIUM INJURY IN RATS. SCIENTIFIC JOURNAL OF KURDISTAN UNIVERSITY OF MEDICAL SCIENCES, 23(2 (94) ), 70-80. SID. https://sid.ir/paper/76378/en

Vancouver: Copy

MAZANI M., MAHMOODZADEH Y., REZAGHOLIZADEH L.. THE PROTECTIVE EFFECTS OF TANACETUM PARTHENIUM EXTRACT ON CCL₄-INDUCED MYOCARDIUM INJURY IN RATS. SCIENTIFIC JOURNAL OF KURDISTAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2018;23(2 (94) ):70-80. Available from: https://sid.ir/paper/76378/en

IEEE: Copy

M. MAZANI, Y. MAHMOODZADEH, and L. REZAGHOLIZADEH, “THE PROTECTIVE EFFECTS OF TANACETUM PARTHENIUM EXTRACT ON CCL₄-INDUCED MYOCARDIUM INJURY IN RATS,” SCIENTIFIC JOURNAL OF KURDISTAN UNIVERSITY OF MEDICAL SCIENCES, vol. 23, no. 2 (94) , pp. 70–80, 2018, [Online]. Available: https://sid.ir/paper/76378/en

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