Radiobiological comparison of 3D conformal and intensity modulated radiation therapy in the treatment of left-sided breast cancer

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Shanei A.; AMOUHEIDARI A.; ABEDI I.; KAZEMZADEH A.; JAAFARI A.

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Journal Paper

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Journal: International Journal of Radiation Research Year:2020 | Volume:18 | Issue:2 Page(s): 315-322

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Title

Radiobiological comparison of 3D conformal and intensity modulated radiation therapy in the treatment of left-sided breast cancer

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Keywords

Radiobiological evaluation

left-sided breast cancer

three dimensional conformal and intensity-modulated radiation therapy

Abstract

Background: The current study aimed to compare the tumor control probability (TCP) and normal tissue complication probability (NTCP) of threedimensional conformal radiation therapy (3D-CRT) and intensity-modulated radiation therapy (IMRT) for left-sided breast cancer using radiobiological models. Methods: This study was conducted on 30 patients with left-sided breast cancer, who were planned for 3D-CRT and 6-9 fields IMRT treatments using the PROWESS treatment planning system. The planning target volume (PTV) dose of 50 Gy was administered for the 3D-CRT and IMRT plans, respectively. The Niemierko’ s equivalent uniform dose (EUD) model was utilized for the estimation of tumor control probability (TCP) and normal tissue complication probability (NTCP). Results: According to the results, the mean TCP values for 3D-CRT, 6-fields IMRT, and 9-fields IMRT plans were 99. 07 ± 0. 07, 99. 24 ± 0. 05 and 99. 28 ± 0. 04, respectively, showing no statistically significant difference. The NTCPs of the lung and heart were considerably lower in the IMRT plans, compared to those in the 3D-CRT plans. Conclusions: From the radiobiological point of view, our results indicated that 3D-CRT produces a lower NTCP for ipsilateral lung. In contrast, for TCP calculations, there was a higher gain with IMRT plans compared to 3D-CRT plans.

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APA: Copy

Shanei, A., AMOUHEIDARI, A., ABEDI, I., KAZEMZADEH, A., & JAAFARI, A.. (2020). Radiobiological comparison of 3D conformal and intensity modulated radiation therapy in the treatment of left-sided breast cancer. INTERNATIONAL JOURNAL OF RADIATION RESEARCH, 18(2), 315-322. SID. https://sid.ir/paper/764250/en

Vancouver: Copy

Shanei A., AMOUHEIDARI A., ABEDI I., KAZEMZADEH A., JAAFARI A.. Radiobiological comparison of 3D conformal and intensity modulated radiation therapy in the treatment of left-sided breast cancer. INTERNATIONAL JOURNAL OF RADIATION RESEARCH[Internet]. 2020;18(2):315-322. Available from: https://sid.ir/paper/764250/en

IEEE: Copy

A. Shanei, A. AMOUHEIDARI, I. ABEDI, A. KAZEMZADEH, and A. JAAFARI, “Radiobiological comparison of 3D conformal and intensity modulated radiation therapy in the treatment of left-sided breast cancer,” INTERNATIONAL JOURNAL OF RADIATION RESEARCH, vol. 18, no. 2, pp. 315–322, 2020, [Online]. Available: https://sid.ir/paper/764250/en

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